Oxygen self-supplied BTOv-Ru heterojunction boosts the sonodynamic antibacterial efficiency of scaffold
Source abstract
Abstract
Transplantation-related bacterial infections often slow new tissue regeneration and even cause transplant failure. Sonodynamic therapy is a promising antibacterial method, which kills bacteria by triggering sonosensitizers to generate reactive oxygen species (ROS). Nevertheless, the generation efficiency of ROS is hindered by the fast electron-hole pair recombination in sonosensitizers and the hypoxic of bacteria microenvironment. Herein, ruthenium nanoparticles (Ru NPs) are grown in-situ on the oxygen vacancies-rich barium titanate nanoparticles (BTOv NPs) to form a Schottky heterojunction. The resulting BTOv-Ru NPs as sonosensitizers is uniformly distributed with poly-L-lactic acid (PLLA) powders to fabricate ultrasound-responsive scaffolds via selective laser sintering. On the one hand, the Schottky heterojunction facilitates electron injection from BTOv to Ru, while the resultant charge separation significantly suppresses electron-hole recombination. On the other hand, the catalase-like activity of Ru catalyzes the overexpressed hydrogen peroxide to generate O2 to achieve O2 self-supply. This not only alleviates hypoxia but also facilitates the oxygen vacancies of BTOv adsorb more O2 to generate ROS. The results confirmed PLLA/BTOv-Ru scaffold generated numerous ROS and exhibited excellent antibacterial effects under ultrasonic irradiation, with inhibiting E. coli (89.3 %) and S. aureus (88.1 %). This O2 self-supplying sonodynamic therapy shows great promise in antibacterial treatment.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Bone Tissue Engineering Materials · Luminescence Properties of Advanced Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
Show source-provided references
1. Trapping effect of surface deficient cocrystal synergizes with bimetallic nanoparticles against bacterial infection in wounds10.1016/j.jcis.2025.137805 ↗
2. Initiative ROS generation of Cu-doped ZIF-8 for excellent antibacterial performance
3. Copper-Based biomaterials for anti-tumor therapy: recent advances and perspectives10.1016/j.actbio.2025.01.014 ↗
4. Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy
5. Recent advances in sonodynamic-derived synergistic strategies against bacterial infections10.1016/j.cej.2025.160962 ↗
6. Bifunctional MoS2@Cu2O heterojunction within scaffold for dual-mode synergistic antibacterial effects10.1016/j.apsusc.2024.162154 ↗
7. Oxygen-supplying nanotherapeutics for bacterial septic arthritis via hypoxia-relief-enhanced antimicrobial and anti-inflammatory phototherapy10.1016/j.jconrel.2025.02.054 ↗
8. Enhanced piezocatalytic therapy of MRSA-infected osteomyelitis using ultrasound-triggered copper nanocrystals-doped barium titanate
9. Visual location of oxygen vacancies on bismuth titanate nanosheets with periodic quantum well and promoting H2O2 photosynthesis
10. Oxygen vacancy-engineered BaTiO3 nanoparticles for synergistic cancer photothermal, photodynamic, and catalytic therapy10.1007/s12274-022-4336-0 ↗
11. A multimodal defect-rich nanoreactor triggers sono-piezoelectric tandem catalysis and iron metabolism disruption for implant infections10.1126/sciadv.ads8694 ↗
12. Local electronic structure modulation of interfacial oxygen vacancies promotes the oxygen activation capacity of Pt/Ce1–xMxO2−δ10.1021/acscatal.3c06234 ↗
13. Ruthenium single-atom nanozyme driven sonosensitizer with oxygen vacancies enhances electron–hole separation efficacy and remodels tumor microenvironment for sonodynamic-amplified ferroptosis
14. Impact of oxygen vacancy occupancy on piezo-catalytic activity of BaTiO3 nanobelt10.1016/j.apcatb.2020.119340 ↗
15. Role of heterogenous microstructure and deformation behavior in achieving superior strength-ductility synergy in zinc fabricated via laser powder bed fusion10.1088/2631-7990/ad3929 ↗
16. Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration10.1016/j.jcis.2024.11.167 ↗
17. Mitochondria-targeted ros scavenging natural enzyme cascade nanogels for periodontitis treatment via hypoxia alleviation and immunomodulation10.1002/advs.202507481 ↗
18. HCP-to-FCC phase transformation of ruthenium nanocrystals selectively activate hydrogen peroxide for boosting peroxidase-like activity10.1021/acsnano.4c14346 ↗
19. Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury
20. Laser powder bed fusion of biodegradable magnesium alloys: process, microstructure and properties10.1088/2631-7990/ad967e ↗
21. Persistent glutathione-depleting MFO@MIL nanoreactors enhance the antitumor efficiency of a skin scaffold10.1039/D4QM01014K ↗
22. Phase-field modeling of laser sintering degradable biopolymer
23. Tumor microenvironment-responsive thermoelectric scaffold for on-demand antitumor therapy
24. Semiconducting titanate supported ruthenium clusterzymes for ultrasound-amplified biocatalytic tumor nanotherapies
25. Triple interface optimization of Ru-based electrocatalyst with enhanced activity and stability for hydrogen evolution reaction
26. Piezo-photoelectronic coupling effect of BaTiO3@TiO2 nanowires for highly concentrated dye degradation10.1016/j.nanoen.2021.106702 ↗
27. Achieving ultrahigh energy storage density for BaTiO3-based ceramics under moderate electric fields via regulating dielectric permittivity10.1021/acsami.5c04646 ↗
28. Phase-dependent synthesis of ru grown on TiO2 for solar driven H2 evolution10.1021/acssuschemeng.5c00412 ↗
29. Ru nanoworms loaded TiO2 for their catalytic performances toward CO oxidation10.1021/acsami.0c20181 ↗
30. Heterostructured piezocatalytic nanoparticles with enhanced ultrasound response for efficient repair of infectious bone defects10.1016/j.actbio.2023.10.006 ↗
31. Piezoelectricity regulated ohmic contact in M/BaTiO3 (M = Ru, Pd, Pt) for charge collision and hydrogen free radical production in ammonia electrosynthesis10.1016/j.mattod.2023.03.011 ↗
32. Multi-electron collaborative photo-Fenton-like system for indoor air purification: a case study of Cu(II) grafted BaTiO3 with oxygen vacancies10.1016/j.jece.2023.111781 ↗
33. Enhanced photodynamic antimicrobial performance of WO3/CuxO double Z-type heterojunction using carrier multichannel conversion10.1016/j.jcat.2024.115924 ↗
34. The predominant factor influencing cellular behavior on electrospun nanofibrous scaffolds: wettability or surface morphology?10.1016/j.matdes.2022.110580 ↗
35. Hydrophilic surface-modified 3D printed flexible scaffolds with high ceramic particle concentrations for immunopolarization-regulation and bone regeneration10.1039/D3BM00362K ↗
36. Electroactive BaTiO3 nanoparticle-functionalized fibrous scaffolds enhance osteogenic differentiation of mesenchymal stem cells10.2147/IJN.S135605 ↗
37. Engineering a wirelessly self-powered neural scaffold based on primary battery principle to accelerate nerve cell differentiation10.1016/j.colsurfb.2025.114521 ↗
38. 3D-printed auxetic ionic hydrogels with moisture retention and high sensitivity for sustainable wearable sensing10.1021/acs.biomac.5c00238 ↗
39. Ultra-soft, foldable, wearable piezoelectric sensor based on the aligned BaTiO3 nanoparticles
40. Fabrication of thermoplastic polyurethane composites with a high dielectric constant and thermal conductivity using a hybrid filler of CNT@BaTiO3
41. Designing osteogenic interfaces on 3D-Printed thermoplastic bone scaffolds
42. PLLA/(MWCNTs-ZnO)@PDA composite with NIR-light induced shape memory effect, antibacterial properties and 3D printability
43. Controlled preparation of Fe3O4/PLA composites and their properties10.1007/s11696-021-01809-2 ↗
44. Indium oxide with oxygen vacancies boosts O2 adsorption and activation for electrocatalytic H2O2 production10.1039/D4CC03361B ↗
45. Oxygen vacancies promoted the selective photocatalytic removal of NO with blue TiO2 via simultaneous molecular oxygen activation and photogenerated hole annihilation10.1021/acs.est.8b07322 ↗
46. Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection10.1016/j.biomaterials.2024.122532 ↗
47. Oxygen vacant semiconductor photocatalysts10.1002/adfm.202100919 ↗
48. Piezoelectric Ba0.85Sr0.15TiO3 nanosonosensitizer with nitric oxide delivery for boosting cancer therapy10.1002/smtd.202301134 ↗
49. Photocatalytic antibacterial scaffold for inhibiting bacterial infection: carriers separation, ROS generation and antibacterial action
50. Construction of a BaTiO3/tubular g-C3N4 dual piezoelectric photocatalyst with enhanced carrier separation for efficient degradation of tetracycline10.1016/j.cej.2023.141947 ↗
51. Palladium-catalyzed hydrogenation of black barium titanate for multienzyme-piezoelectric synergetic tumor therapy
52. Self-augmented catabolism mediated by Se/Fe co-doped bioceramics boosts ROS storm for highly efficient antitumor therapy of bone scaffolds10.1016/j.colsurfb.2024.114477 ↗
53. An NIR-driven upconversion/C3N4/CoP photocatalyst for efficient hydrogen production by inhibiting electron–hole pair recombination for alzheimer’s disease therapy10.1021/acsnano.2c08499 ↗
54. A new insight into balancing reactive oxygen species in piezodynamic therapy10.1002/adfm.202513106 ↗