COLLOIDS AND SURFACES B-BIOINTERFACES

Shihao Zhang, Chenxi Zhang, Xu Li, Dong Zhou et al.

Skin burns remain challenging in clinical treatment due to their complex wound morphology, high oxidative stress, hypoxic microenvironment, and severe inflammatory response. Developing strategies for highly effective biomaterials with precise biological functions has become an urgent priority in addressing clinical challenges. This study developed a fluffy fibrous scaffold load…

Fangwei Qi, Mingming Xia, Xiuwen Gao, jingxi Huang et al.

Electrical stimulation is limited in promoting peripheral nerve regeneration due to its reliance on external electrodes and wires. Herein, a wireless powered system is constructed based on capacitive coupling effect. In detail, an insulated copper sheet as the transmitting electrode, and a MXene/PDA/PLLA nerve conduit with a three-dimensional continuous conductive network serve…

M Zhang, Ning Wang, Xiaoxia Liu, Yue Wang et al.

Cancer immunotherapy based on nanovaccines aims to elicit specific anti-tumor immune responses, demonstrating significant therapeutic potential. However, its clinical translation remains hindered by two major challenges: inadequate immunogenicity of the vaccine itself and limited antigen presentation efficiency in dendritic cells (DCs). To overcome these bottlenecks, we have de…

Jie Zeng, Jianying He, Gan Chen, Duo-Duo Wei et al.

Most traditional photosensitizers (PSs) are excited by visible light or the first near-infrared window (NIR-I) exhibited high tissue scattering and shallow less tissue penetration depth. Besides, single phototherapy has the disadvantage of poor treatment effect. Herein, the three PSs were designed and synthesized. Among them, the ISO-HZF molecule can be excited by near-infrared…

Xiaoyang Chen, Yao Li, Zilong Wang, Songkai Yue et al.

Osteoarthritis (OA) is characterized by sterile intra-articular inflammation and progressive cartilage degeneration. Nanoparticle-based photothermal therapy (PTT) offers a promising intervention for OA therapy; however, drug-release control under photothermal conditions remains underexplored. Here, we present a Prussian blue-based, near-infrared (NIR) -responsive hydrogel (GPT)…

Kunjie Ran, Yi-Xiang Wang, Dingwei Li, Zhijiang Jiang et al.

Abstract not available. Bibliographic information is searchable.

Jie Gao, Li Li, Bin Hu, Yukang Que et al.

Diabetic bone defects are difficult to repair because chronic hyperglycemia creates a hostile inflammatory and oxidative microenvironment that impairs osteogenesis, enhances osteoclast activity and compromises vascular ingrowth. Plant-derived extracellular vesicle-like nanoparticles can transfer source-related biological signals to mammalian cells and are attractive for immune …

Thu‐Ha Thi Nguyen, Hao Thi Tran, Anh-Thuy Lam, Nhu‐Thuy Trinh et al.

Liver fibrosis is a chronic pathological condition caused by repeated or sustained liver injury, for which effective pathological treatments remain limited. Silymarin, a hydrophobic compound with anti-inflammatory, antioxidant, and antifibrotic properties, has shown therapeutic potential. However, its clinical application is restricted by poor aqueous solubility and low gastroi…

Omar Gahbiche, Ridha Ajjel, Elaa Chiba, Riadh Marzouki et al.

This study reports a multifunctional Pt@TiO₂-rGO nanocomposite synthesized via a one-step solvothermal method and further PEGylated to enhance colloidal stability for biomedical applications. The nanocomposite integrates ultrasound-activated sonodynamic therapy (SDT), sono-thermal effects, radiotherapy dose enhancement, and enzyme-mimetic catalytic activity. Under ultrasound ir…

Neeraj S. Thakur, Vibhuti Agrahari, Yogeshvar N. Kalia

Micellar systems are transformed upon contact with the stratum corneum lipids, disassembling and releasing their cargo. Thus, the development of micellar systems for sustained cutaneous delivery that retain structural integrity poses considerable challenges. Herein, a highly stable crosslinked hybrid micellar (cHy-Micelles) platform is developed for controlled cutaneous drug de…

Marzieh Lotfi, Mojtaba Shafiee, Altynay Sharipova, Saule Aidarova et al.

Cisplatin-loaded biopolymeric nanogels are promising carriers for sustained anticancer drug delivery; however, establishing physically interpretable links between formulation structure, transport behavior, and temperature-dependent release remains challenging. Here, mucilage-alginate-coated chitosan (MACC) nanogels were developed and evaluated using an integrated framework comb…

Zhengjie Meng, Zi Wang, Chenyu Lu, Fei Xue et al.

Acute kidney injury (AKI) is a severe syndrome driven by oxidative stress and inflammation, with limited effective drug therapy. Total flavonoids (Fla) from Abelmoschus manihot (L.) Medic have strong antioxidant and anti-inflammatory activity, but poor solubility and weak renal targeting limit its clinical translation. Here, a nephritis microenvironment-responsive dual-targetin…

A. Castillejo, Guillermo Martínez, Ernesto J. Delgado-Pujol, David Casado-Jurado et al.

The treatment of osteochondral defects remains one of the most significant challenges in regenerative medicine due to the limited self-repair capacity of articular cartilage. This study proposes a multidisciplinary approach through the design and fabrication of an innovative biphasic scaffold (BS) that integrates a porous commercially pure titanium (c.p. Ti) substrate with a su…

Ze Zhang, Zhipeng Huang, Chenghan Zhang, Weiping Qin et al.

An innovative dual-wavelength-responsive GMMC-Pdots-Ag hydrogel was fabricated for the treatment of polymicrobial-infected liver and skin defects. The hydrogel is based on a dynamic double-network architecture composed of gelatin methacryloyl (GelMA), O-carboxymethyl chitosan (O-CMC), and 4-arm poly(ethylene glycol) benzaldehyde (4-arm-PEG-DF), co-loaded with PtOEP-doped T2-DPP…

Álvaro Gutiérrez, Juan Machuca, Carolina Larronde, Emilio Villarroel et al.

Understanding the molecular intricacies of Pediocin PA-1 interactions with biological membranes reveals a distinctive mechanism with promising implications beyond its effects on prokaryotic membranes. To elucidate the behavior of this bacteriocin, molecular dynamics simulations were performed under both NVT and NPT ensembles, as well as with NγT to accelerate biological process…

Menglin Huang, Xue Yang, Hongjing Wu, Weiwei Li et al.

Diabetic wound healing remains a complex scientific challenge due to the extremely complex microenvironment, including sustained hypoxia, high levels of reactive oxygen species (ROS), repeated bacterial infection, and abnormal immune regulation. Herein, a tunable adhesive hydrogel (PTA@Hydrogel) is constructed that regulates the immune microenvironment to accelerate diabetic wo…

Junhui Ma, C S Wang, Chaojie Li, Qianlong Wang et al.

Paclitaxel (PTX) chemotherapy is severely limited by poor aqueous solubility, off-target toxicity, and P-glycoprotein-mediated multidrug resistance (MDR). Herein, we report a redox-responsive prodrug nanosystem, SOL-SS-PTX, constructed by conjugating PTX to the bioactive natural polyisoprenoid solanesol (SOL) via a disulfide bond. Unlike conventional polymer- or lipid-based car…

Zha Yang, Siqi Yang, Yi Ran, Tangqing Zhang et al.

Hyperuricemia-associated renal injury involves coordinated disturbances in urate transport, tubular inflammation, and gut-kidney metabolic homeostasis. Here, we evaluated Perilla frutescens-derived exosome-like nanovesicles (PLENs) as an orally deliverable natural vesicle platform for this condition. PLENs showed stable nanoscale vesicular features and maintained structural com…

Iñaki García-Arnáez, Francisco Romero‐Gavilán, Andreia Cerqueira, Fabio Savastano et al.

Ionic functionalization of biomaterial coatings has emerged as a powerful strategy to regulate early host responses at the implant interface. However, how combined Ca/Sr incorporation governs the adsorbed proteome and downstream immune signaling remains poorly understood. This study analyses, employing in vitro tests and proteomics, the effect of adding Sr and Ca to Si-based co…

Yueping Bai, Linxuan Shi, Lu Liu, Li Cui et al.

The formation of bacterial biofilms at infection sites represents a major obstacle to the effective healing of diabetic wounds. Biofilm-associated diabetic wounds are exceedingly difficult to manage, compounded by the increasing prevalence of antibiotic-resistant strains and the limited pipeline of novel antibacterial agents. To address this challenge, we designed polydopamine-…