Polymeric micelles for acyclovir drug delivery
Source abstract
Abstract
Polymeric prodrug micelles for delivery of acyclovir (ACV) were synthesized. First, ACV was used directly to initiate ring-opening polymerization of ɛ-caprolactone to form ACV-polycaprolactone (ACV-PCL). Through conjugation of hydrophobic ACV-PCL with hydrophilic methoxy poly(ethylene glycol) (MPEG) or chitosan, polymeric micelles for drug delivery were formed. (1)H NMR, FTIR, and gel permeation chromatography were employed to show successful conjugation of MPEG or chitosan to hydrophobic ACV-PCL. Through dynamic light scattering, zeta potential analysis, transmission electron microscopy, and critical micelle concentration (CMC), the synthesized ACV-tagged polymeric micelles were characterized. It was found that the average size of the polymeric micelles was under 200nm and the CMCs of ACV-PCL-MPEG and ACV-PCL-chitosan were 2.0mgL(-1) and 6.6mgL(-1), respectively. The drug release kinetics of ACV was investigated and cytotoxicity assay demonstrates that ACV-tagged polymeric micelles were non-toxic.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Drug Delivery Systems · RNA Interference and Gene Delivery · HIV Research and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (40)
Show source-provided references
1. Physical and biocompatibility properties of poly-ɛ-caprolactone produced using in situ polymerisation: a novel manufacturing technique for long-fibre composite materials10.1016/S0142-9612(99)00236-7 ↗
2. Polymer therapeutics-prospects for 21st century: the end of the beginning10.1016/j.addr.2012.08.012 ↗
3. Chitosan-graft-poly(ɛ-caprolactone)s: an optimized chemical approach leading to a controllable structure and enhanced properties10.1002/pola.22015 ↗
4. Biodegradable polymeric nanoparticles as drug delivery devices10.1016/S0168-3659(00)00339-4 ↗
5. Stability and release of antiviral drugs from ethylene vinyl acetate (EVA) copolymer10.1007/s10856-006-0596-6 ↗
6. Novel chitosan-derived nanomaterials and their micelle-forming properties10.1021/jf061541w ↗
7. Micellar nanocarriers: pharmaceutical perspectives10.1007/s11095-006-9132-0 ↗
8. Block copolymer micelles for drug delivery: design, characterization and biological significance10.1016/S0169-409X(00)00124-1 ↗
9. In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: effects of PEG chain length and PC incorporation10.1002/jps.20150 ↗
10. Multifunctional and thermoresponsive unimolecular micelles for tumor-targeted delivery and site-specifically release of anticancer drugs10.1016/j.polymer.2012.05.056 ↗
11. Current and future ophthalmic drug delivery systems: a shift to the posterior segment10.1016/j.drudis.2007.11.002 ↗
12. Development of the polymer micelle carrier system for doxorubicin10.1016/S0168-3659(01)00341-8 ↗
13. Polymer micelles as novel drug carrier-adriamycin-conjugated poly(ethylene glycol) poly(asparic acid) block copolymer10.1016/0168-3659(90)90139-K ↗
14. Novel SN-38—incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor—secreting bulky tumors10.1158/0008-5472.CAN-06-1605 ↗
15. Acyclovir a review of its pharmacodynamic properties and therapeutic efficacy10.2165/00003495-198326050-00002 ↗
16. Curability of tumors bearing herpes thymidine kinase genes transfered by retroviral vectors10.1093/jnci/82.4.297 ↗
17. Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity10.1046/j.1464-410x.2000.00516.x ↗
18. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo10.1073/pnas.91.8.3054 ↗
19. Suicide gene therapy mediated by the herpes simples virus thymidine kinase gene/ganciclovir system: fifteen years of application10.2174/1566523033347426 ↗
20. Novel designed polymer–acyclovir conjugates with linker-controlled drug release and hepatoma cell targeting10.1002/pola.22363 ↗
21. Studies on acyclovir–dextran conjugate: synthesis and pharmacokinetics10.1081/DDC-200037232 ↗
22. Syntheses, chemical and enzymatic stability of new poly(ethylene glycol)–acyclovir prodrugs10.1016/S0014-827X(01)01193-4 ↗
23. Bioadhesive microspheres for ophthalmic administration of acyclovir10.1111/j.2042-7158.1997.tb06103.x ↗
24. Development of mucoadhesive microspheres of acyclovir with enhanced bioavailability10.1016/j.ijpharm.2009.05.025 ↗
25. Enhanced transdermal delivery of acyclovir sodium via elastic liposomes10.1080/10717540801952407 ↗
26. Guanosine-based antiviral acyclovir incorporated in ring-opening polymerization of ɛ-caprolactone
27. Self-assembled, thermosensitive PCL-g-P(NIPAAm-co-HEMA) micelles for drug delivery10.1002/marc.200600521 ↗
28. Chitosan microspheres as a potential carrier for drugs10.1016/j.ijpharm.2003.12.026 ↗
29. Poly-ɛ-caprolactone based formulations for drug delivery and tissue engineering: a review10.1016/j.jconrel.2011.09.064 ↗
30. Self-assembled star-shaped chlorin-core poly(ɛ-caprolactone)–poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies10.1016/j.biomaterials.2008.05.018 ↗
31. Aliphatic polyesters. III: Molecular weight and molecular weight distribution in alcohol-initiated polymerizations of ɛ-caprolactone
32. Micelles of methoxy poly(ethylene oxide)-b–poly(ɛ-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A10.1016/j.jconrel.2005.02.015 ↗
33. Aliphatic polyester-grafted starch-like polysaccharides by ring-opening polymerization10.1016/S0032-3861(98)00110-4 ↗
34. Chitosan and its derivatives for drug delivery perspective
35. Emerging PEGylated drugs10.1517/14728210902907847 ↗
36. PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases10.1016/S0165-0270(01)00450-2 ↗
37. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study10.1021/ma00005a010 ↗
38. Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems10.1021/ja00449a004 ↗
39. Polymer nanoparticles10.1016/B978-0-12-416020-0.00007-3 ↗
40. Synthesis and micellization of star-shaped poly(ethylene glycol)-block–poly(ɛ-caprolactone)10.1002/macp.200400084 ↗