Ozone-induced grafting phosphorylcholine polymer onto silicone film grafting 2-methacryloyloxyethyl phosphorylcholine onto silicone film to improve hemocompatibility
Source abstract
Abstract
Abstract Ozonization, a novel surface modification method, has been developed to improve hemocompatibility of polymeric biomaterials. The silicone film was exposed to ozone and then followed by grafted polymerization with 2-methacryloyloxyethyl phosphorylcholine (MPC). The surface graft polymerization was confirmed by X-ray photon spectroscopy and ATR-FTIR. Surface hydrophilicity was investigated by measuring the contact angles and MPC polymer grafted silicone film show a significant increase in hydrophilicity. The blood compatibility of the grafted film was evaluated by a platelet-rich plasma (PRP) adhesion study and scanning electron microscopy, using silicone film as the reference. No platelet adhesion was observed on the grafted film incubated with PRP at 37 °C for 60 and 180 min. The ozonization is an effective method to graft MPC onto the silicone surface with many advantages and therefore very useful for practical application of blood contacting medical devices.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (27)
Show source-provided references
1. Blood compatible polymers
2. Molecular engineering research on polymeric biomaterials
3. Proteins’ natural conformation and biomaterials’ biocompatibility
4. Synthesis studies on blood compatible materials (VII): a novel kind of platelet adhesion resistant polymers
5. Synthetic studies on blood compatible materials, Poly (ether-urethane) surface grafted with sulfo-ammonium zwitterionic monomer activated by ozone
6. Grafted sulfobetaine monomer onto the segmented poly (ether-urethane) surface to improve hemocompatibility10.1163/156856202320813800 ↗
7. J. Yuan, J. Zhang, X.P. Zang, J. Shen, S.C. Lin, Improvement of blood compatibility on cellulose membrane surface by grafting betaines, Colloids and Surfaces B: Biointerfaces, in press.10.1016/S0927-7765(03)00082-1 ↗
8. Y.L. Yuan, X.P. Zang, F. Ai, J. Jiang, J. Zhou, J. Shen, S. Lin, Surface modification of SPEU film by ozone induced graft copolymerization to improve hemocompatibility, Colloids and Surfaces B: Biointerfaces, in press.10.1016/S0927-7765(02)00210-2 ↗
9. Surface modification of segmented poly (ether urethane) by grafting sulfo-zwitterionic monomer to improve hemocompatibilities10.1016/S0927-7765(02)00116-9 ↗
10. Synthetic studies on blood compatible biomaterials B: a novel segmented polyurethane containing phosphorylcholine structure: synthesis, characterization and blood compatibility evaluation
11. Preparation of phospholipid polymers and their properties as polymer hydrogel membranes10.1295/polymj.22.355 ↗
12. Bioinspired phospholipid polymer biomaterials for making high performance artificial organs10.1016/S1468-6996(00)00012-7 ↗
13. Photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on polyethylene membrane surface for obtaining blood cell adhesion resistance10.1016/S0927-7765(99)00158-7 ↗
14. Antithrombogenic polymer alloy composed of 2-methacryloyloxyethyl phosphorylcholine polymer and segmented polyurethane10.1163/156856200744264 ↗
15. Synthesis, characterization and platelet adhesion of segmented polyurethane grafted phospholipid analogous vinyl monomer on surface10.1016/S0142-9612(01)00104-1 ↗
16. Synthesis of phospholipid polymers having a urethane bond in the side chain as coating material on segmented polyurethane and their platelet adhesion-resistant properties10.1016/0142-9612(95)94150-J ↗
17. Synthesis and characterization of phosphorylcholine-based polymers useful for coating blood filtration devices10.1016/S0142-9612(00)00055-7 ↗
18. Improvement of blood compatibility on cellulose dialysis membrane, synthesis and performance of water-soluble cellulose grafted with phospholipid polymer as coating material on cellulose dialysis membrane10.1002/jbm.820290207 ↗
19. Interaction between phospholipids and biocompatible polymers containing a phosphorylcholine moiety10.1016/0142-9612(91)90189-H ↗
20. Novel biomedical polymers for regulating serious biogical reactions10.1016/S0928-4931(98)00059-9 ↗
21. Hemocompatibility on graft copolymers composed of 2-methacryloyloxyethyl phosphorylcholine side chain and poly (n-butyl methacrylate) backbone10.1002/jbm.820280213 ↗
22. Ozone-induced graft polymerization onto polymer surface10.1002/pola.1993.080310426 ↗
23. Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surface by ozone oxidation10.1016/S0142-9612(00)00400-2 ↗
24. Iodometric determination of peroxygen in organic compounds10.1021/ja01850a082 ↗
25. Grafting of acrylic acid onto radiation-peroxidized polypropylene film in the presence of ferrous ion10.1002/pol.1972.150100221 ↗
26. Platelet adhesion onto segmented polyurethane film surfaces modified by addition and crosslinking of PEO-containing block copolymers10.1016/S0142-9612(99)00197-0 ↗
27. Blood compatible phospholipid-containing polyurethane, synthesis, characterization and blood compatibility evaluation10.1177/088532829701200205 ↗