A multitechnique approach on adsorption, self-assembly and quercetin solubilization by Tetronics® micelles in aqueous solutions modulated by glycine
Source abstract
Abstract
Ethylene oxide-propylene oxide (EO-PO) block copolymer micelles are useful potential nanoreservoirs for the delivery of hydrophobic drugs. Considering that glycine is an excipient and can favorably affect the surface/micellar behavior and thus improve solubilization power/dispersion stability/wetting characteristics we have reported here studies on aqueous solution behavior of two commercially available branched block copolymers (Tetronics®) with differing hydrophobicities namely Tetronics® 1307 and 1304, hereafter referred as T1307 and T1304, in the presence of glycine. Steady state fluorescence studies using pyrene as a probe, equilibrium and dynamic surface tension measurements, wetting and dispersion stability studies of Teflon (polytetrafluoroethylene; PTFE) and solubilization studies of a hydrophobic antioxidant/anticancer drug quercetin (QN) have been examined. The cloud point (CP) and critical micelle temperature (CMT) decrease while micelle hydrodynamic size (Dh) increases with the addition of glycine as well as on loading of the drug in the micelles. Water penetration through packed PTFE powder and dynamic surface tension confirm the enhanced micellization process for aqueous Tetronic® solutions in presence of glycine and accordingly restricted diffusion for the surfactant molecules towards air-water and PTFE-water interface. The contact angles for Tetronic® solutions in presence of glycine indicate moderate decrease. The pressure-area curves of the copolymers in water and glycine solutions were also constructed. Surface and micellar properties of copolymers are markedly altered in the presence of glycine and can be tuned for use of these nanocarriers in delivery systems.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Surfactants and Colloidal Systems · Advanced Polymer Synthesis and Characterization · Electrostatics and Colloid Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (74)
Show source-provided references
1. Micellization of block copolymers10.1016/S0079-6700(03)00015-7 ↗
2. Self-assembly of block copolymers10.1039/c2cs35115c ↗
3. Dynamics of block copolymers: theory and experiment10.1146/annurev.ms.26.080196.002441 ↗
4. Poly(ethylene oxide)/poly(propylene oxide) block copolymer surfactants10.1016/S1359-0294(97)80095-7 ↗
5. Aggregation of water-soluble block copolymers in aqueous solutions: recent trends10.1016/j.cis.2006.05.016 ↗
6. Aggregation behavior of star-like PEO–PPO–PEO block copolymer in aqueous solution10.1016/j.eurpolymj.2007.04.005 ↗
7. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers10.1016/j.addr.2012.09.026 ↗
8. Block copolymer micelles for drug delivery: design, characterization and biological significance10.1016/S0169-409X(00)00124-1 ↗
9. Nano-engineering block copolymer aggregates for drug delivery10.1016/S0927-7765(99)00058-2 ↗
10. Polymeric micelles as new drug carriers10.1016/S0169-409X(96)00401-2 ↗
11. Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery10.1016/S0168-3659(02)00009-3 ↗
12. Block and graft copolymers and Nanogel™ copolymer networks for DNA delivery into cell10.3109/10611860008996855 ↗
13. Self-assembled and nanostructured hydrogels for drug delivery and tissue engineering10.1016/j.nantod.2009.08.008 ↗
14. Amphiphilic block co-polymers: preparation and application in nanodrug and gene delivery10.1016/j.actbio.2012.03.006 ↗
15. Micellar carriers for the delivery of multiple therapeutic agents10.1016/j.colsurfb.2015.07.046 ↗
16. Tetronic micellization, gelation and drug solubilization: influence of pH and ionic strength10.1016/j.ejpb.2006.10.010 ↗
17. Block copolymer micelles for drug delivery10.1016/j.addr.2012.09.013 ↗
18. Block copolymer micelles as long-circulating drug vehicles10.1016/j.addr.2012.09.016 ↗
19. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
20. Self-assembled polymer nanostructures for delivery of anticancer therapeutics10.1016/j.nantod.2009.06.001 ↗
21. NaCl-triggered self-assembly of hydrophilic poloxamine block copolymers10.1016/j.ijpharm.2015.08.058 ↗
22. Differential scanning calorimetry investigation of the effect of salts on aqueous solution properties of an amphiphilic block copolymer (poloxamer)10.1021/la9703712 ↗
23. Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution10.1016/S0927-7757(00)00493-3 ↗
24. Influence of ionic surfactants on the aggregation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers studied by differential scanning and isothermal titration calorimetry10.1021/jp012729f ↗
25. Influence of 1-pentanol on the micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers in aqueous solutions10.1021/la026584v ↗
26. Effect of ionic liquids on the aggregation behavior of PEO–PPO–PEO block copolymers in aqueous solution10.1021/jp066727c ↗
27. Rowe · 2009
28. Interactions of some amino acids and glycine peptides with aqueous sodium dodecyl sulfate and cetyltrimethylammonium bromide at T=298.15K: a volumetric approach10.1016/j.jct.2003.09.010 ↗
29. A calorimetric study on interactions of amino acids with sodium dodecylsulfate and dodecyltrimethylammonium bromide in aqueous solutions at 298.15K10.1016/j.tca.2008.09.001 ↗
30. Studies on sodium dodecylsulfate in aqueous and in aqueous amino acid solutions: volumetric and viscometric approaches10.1016/j.jct.2013.11.022 ↗
31. Conductivity and fluorescence studies on the micellization properties of sodium cholate and sodium deoxycholate in aqueous medium at different temperatures: effect of selected amino acids10.1016/j.jct.2014.10.014 ↗
32. Organization of amphiphiles, part XII: studies on the interaction of glycine with aqueous micelles of polyoxyethylated nonyl phenols10.1016/j.molliq.2012.09.010 ↗
33. Krafft temperature and thermodynamic study of interaction of glycine, diglycine, and triglycine with hexadecylpyridinium chloride and hexadecylpyridinium bromide: a conductometric approach10.1016/j.molliq.2015.11.017 ↗
34. Interaction of hexadecylpyridinium bromide with glycine in aqueous medium using the Krafft temperature from conductivity measurement10.1016/j.molliq.2016.01.003 ↗
35. Surface tension and UV–vis investigations of aggregation and adsorption behavior of NaC and NaDC in water–amino acid mixtures10.1016/j.fluid.2015.03.012 ↗
36. Aggregation behaviour of octyl-β-thioglucopyranoside in the presence of glycine10.1016/j.colsurfa.2004.08.045 ↗
37. Studies on the effects of amino acids on micellization of CTAB via surface tension measurements10.1016/j.colsurfa.2004.10.066 ↗
38. Surface activity and association behavior of nonaoxyethylene n-dodecylether in aquo amino acid medium: tensiometry, small-angle neutron scattering, dynamic light scattering and viscosity studies10.1016/j.colsurfa.2007.05.035 ↗
39. Tolerability of hypertonic injectables10.1016/j.ijpharm.2015.05.069 ↗
40. Surface activity of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) copolymers10.1021/la00020a019 ↗
41. Poly(ethylene oxide)–poly(propylene oxide)–poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling10.1016/0927-7757(94)03028-X ↗
42. Surface activity and association of ABA polyoxyethylene—polyoxypropylene block copolymers in aqueous solution10.1016/0021-9797(79)90151-6 ↗
43. Micelle formation by oxyethylene-oxypropylene polymers
44. Aggregation behavior of Pluronic P-94 in water10.1021/la00047a016 ↗
45. The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxyethylene)-block-copolymers in aqueous solution10.1007/BF01513189 ↗
46. Adsorption of PEO/PPO triblock co-polymers and wetting of coal10.1016/S0927-7757(98)00794-8 ↗
47. Temperature and salt-induced micellization of some block copolymers in aqueous solution10.1007/s11743-000-0125-0 ↗
48. Pluronic-P105 PEO-PPO-PEO block copolymer in aqueous urea solutions: micelle formation, structure, and microenvironment10.1021/la00007a022 ↗
49. Polymeric micelles for oral drug delivery10.1016/j.ejpb.2010.06.007 ↗
50. Glycine elicited self-assembly of amphiphilic star block copolymers with contradistinct hydrophobicities10.1016/j.colsurfa.2016.06.038 ↗
51. Differences between dynamic and equilibrium surface tension of poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymer surfactants (poloxamers P407, P237, and P338) in aqueous solution10.1021/js960343o ↗
52. Novel strategy involving surfactant—polymer combinations for enhanced stability of aqueous Teflon dispersions10.1021/la5012605 ↗
53. Correlation of dynamic surface tension with sedimentation of PTFE particles and water penetration in powders10.1021/acs.langmuir.5b03725 ↗
54. Adsorption and desorption of PEO-PPO-PEO triblock copolymers on a self-assembled hydrophobic surface10.1021/ma0342675 ↗
55. Phase behavior of mixed langmuir monolayers from amphiphilic block copolymers and an antimicrobial peptide10.1021/la0524216 ↗
56. Fluorescence probe techniques used to study micelle formation in water-soluble block copolymers10.1021/la00092a038 ↗
57. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study10.1021/ma00005a010 ↗
58. Fluorescence probes for critical micelle concentration determination10.1021/la00063a015 ↗
59. Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems10.1021/ja00449a004 ↗
60. On the determination of the critical micelle concentration by the pyrene 1:3 ratio method10.1016/S0021-9797(02)00082-6 ↗
61. Surface and bulk interactions of ionic and nonionic surfactants10.1021/j100274a017 ↗
62. Microenvironmental control of photochemical reactions. 3. Additive effects on micellar structure and properties of TX-10010.1021/la00060a001 ↗
63. Mixed micellization of cetyltrimethylammonium bromide and an anionic dimeric (gemini) surfactant in aqueous solution10.1021/la9606963 ↗
64. Spectroscopic probe analysis of protein-surfactant interactions: the BSA/SDS system10.1021/la00007a035 ↗
65. Fluorescence probe investigation of anionic polymer-cationic surfactant interactions10.1021/ma00182a018 ↗
66. Interactions of surfactants with hydrophobically-modified poly(N-isopropylacrylamides). 1. Fluorescence probe studies10.1021/la00053a016 ↗
67. Photoluminescence probes for the investigation of interactions between sodium dodecylsulfate and water-soluble polymers10.1021/ma00137a005 ↗
68. Effect of urea on aggregation behavior of triton X-100 micellar solutions: a photophysical study10.1006/jcis.1994.1211 ↗
69. Light scattering and fluorescence probe studies on micellar properties of Triton X-100 in KCl solutions10.1080/00268970110068750 ↗
70. Effect of cosolvents and cosolutes upon aggregation transitions in aqueous solutions of the poloxamer F87 (poloxamer P237): a high sensitivity differential scanning calorimetry study10.1021/jp951390s ↗
71. Concentration, temperature, and salt-induced micellization of a triblock copolymer Pluronic L64 in aqueous media10.1016/j.jcis.2005.06.013 ↗
72. Effect of glycine on the surface activity and micellar properties of N-decanoyl-N-methylglucamide10.1007/s00396-008-1893-z ↗
73. Interaction of glycine with cationic, anionic, and nonionic surfactants at different temperatures: a volumetric, viscometric, refractive index, conductometric, and fluorescence probe study10.1007/s00396-007-1750-5 ↗
74. Indomethacin solubilization induced shape transition in C n E 7 (n=14, 16) nonionic micelles10.1016/j.jcis.2007.09.021 ↗