Sc-doped SnS2 monolayer-based promising biosensor FET for lung cancer early diagnosis: an ab-initio study
Source abstract
Abstract
Early diagnosis of lung cancer has gained much attention in the last few years due to its high incidence and fatality rate. In this paper, Sc-doped SnS2 (Sc − SnS2) monolayer is proposed as a promising biosensor to diagnose lung cancer in the early stage. Employing DFT-based investigation, the adsorption mechanism of three prominent biomarkers C3H4O, C3H6O, and C5H8 in the exhaled breath of lung cancer patients is analyzed. The effect of Sc-doping on pristine SnS2 is studied first followed by an investigation of the adsorption mechanism via. structural, magnetic, and electronic properties. Based on binding energy calculations, a single Sc atom adsorbs on the Sn-site of the SnS2 surface and is chosen as a molecular model for adsorption analysis. The findings revealed that the Sc-SnS2 monolayer had exceptional adsorption ability for three common volatile organic compounds (VOCs) found in lung cancer patients, resulting in a significant change in the physicochemical parameters of the sensing Sc-SnS2 system. The results projected Sc − SnS2 monolayer as a promising biosensor to diagnose lung cancer at an early stage and provide a way for experimentalists to explore it in the real application. Moreever, the charge-transfer behavior under the effect of electric field is also examined in order to explicate the expediency of Sc-doped SnS2 monolayer as a field-effect-transistor sensor.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Gas Sensing Nanomaterials and Sensors · Advanced Chemical Sensor Technologies · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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