journal article·2016-09

A new composite scaffold of bioactive glass nanoparticles/graphene: Synchronous improvements of cytocompatibility and mechanical property

Zengjie Fan, Jinqing Wang, Fengzhen Liu, Yingying Nie, Liling Ren, Bin Liu

Publisher page

Abstract

This study presents a simple method of synthesizing bioactive glass nanoparticles/graphene nanosheets composite (BGs/GNS) scaffolds using the sol-gel and mold-compressing strategies. Characterizations of BGs/GNS scaffold revealed that BGs with an average diameter of 28.75nm were densely anchored onto both sides of GNS. When the mass ratio of BGs to graphene oxide was set as 10, this scaffold showed better cytocompatibility and higher osseointegration ability with surrounding tissues than the other scaffolds. The introduction of GNS also significantly enhanced the hardness and Young's modulus of BGs. Given the excellent performance of this scaffold, it has potential applications in bone regeneration and implantation.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Laser-Ablation Synthesis of Nanoparticles

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (52)

Show source-provided references
1. Bioactive glass in tissue engineering10.1016/j.actbio.2011.03.016 ↗
2. Apatite formation of bioactive glasses is enhanced by low additions of fluoride but delayed in the presence of serum proteins10.1016/j.matlet.2015.04.013 ↗
3. Bioactive glasses beyond bone and teeth: emerging applications in contact with soft tissues10.1016/j.actbio.2014.11.004 ↗
4. Bioactive glass reinforced elastomer composites for skeletal regeneration: a review10.1016/j.msec.2015.04.035 ↗
5. Electrophoretic deposition of carbon nanotubes and bioactive glass particles for bioactive composite coatings10.1016/j.ceramint.2009.09.008 ↗
6. A review of bioactive glasses: their structure, properties, fabrication and apatite formation10.1002/jbm.a.34690 ↗
7. Hydroxyapatite formation on sol–el derived poly(ε-caprolactone)/bioactive glass hybrid biomaterials10.1021/am300487c ↗
8. In vitro and in vivo analysis of macroporous biodegradable poly(d,l-lactide-co-glycolide) scaffolds containing bioactive glass10.1002/jbm.a.30433 ↗
9. Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration10.1016/j.actbio.2012.06.040 ↗
10. Effect of ciprofloxacin incorporation in PVA and PVA bioactive glass composite scaffolds10.1016/j.ceramint.2013.09.033 ↗
11. Structure, phases, and mechanical response of Ti-alloy bioactive glass composite coatings10.1016/j.msec.2013.12.017 ↗
12. Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing bioactive glass nanoparticles10.1016/j.carbon.2013.01.014 ↗
13. Characterization of carbon nanotube (MWCNT) containing P(3HB)/bioactive glass composites for tissue engineering applications10.1016/j.actbio.2009.09.023 ↗
14. A novel wound dressing based on Ag/graphene polymer hydrogel: effectively kill bacteria and accelerate wound healing10.1002/adfm.201304202 ↗
15. Integrated graphene/nanoparticle hybrids for biological and electronic applications10.1039/C4NR00612G ↗
16. Wet-spinning assembly of continuous, neat, and macroscopic graphene fiber10.1038/srep00613 ↗
17. Graphene-based macroscopic assemblies and architectures: an emerging material system10.1039/C4CS00181H ↗
18. Aqueous phase preparation of graphene with low defect density and adjustable layers10.1039/c3cc46809g ↗
19. Enhancement mechanisms of graphene in nano-58S bioactive glass scaffold: mechanical and biological performance
20. Graphene-based materials biocompatibility: a review10.1016/j.colsurfb.2013.05.022 ↗
21. Bioinspired, ultrastrong, highly biocompatible, and bioactive natural polymer/graphene oxide nanocomposite films10.1002/smll.201500486 ↗
22. Graphene-based materials biocompatibility: a review10.1016/j.colsurfb.2013.05.022 ↗
23. Preparation of graphitic oxid10.1021/ja01539a017 ↗
24. Effect of the oxygen-containing functional group of graphene oxide on the aqueous cadmium ions removal10.1016/j.apsusc.2014.12.090 ↗
25. Preparation of covalently functionalized graphene using residual oxygen-containing functional groups10.1021/am100597d ↗
26. Silica-graphene oxide hybrid composite particles and their electroresponsive characteristics10.1021/la3009283 ↗
27. A route towards superhydrophobic graphene surfaces: surface-treated reduced graphene oxide spheres10.1039/c3ta11434a ↗
28. Graphene oxide/hydroxyapatite composite coatings fabricated by electrochemical deposition10.1016/j.surfcoat.2015.12.013 ↗
29. Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite10.1016/j.carbon.2013.11.054 ↗
30. Silica-graphene oxide hybrid composite particles and their electroresponsive characteristics10.1021/la3009283 ↗
31. Preparation of graphene by the rapid and mild thermal reduction of graphene oxide induced by microwaves10.1016/j.carbon.2009.11.037 ↗
32. Apatite wollastonite–poly methyl methacrylate bio-composites10.1016/j.msec.2009.01.019 ↗
33. Bioactive glass nanoparticles obtained through sol-gel chemistry10.1039/c3cc00003f ↗
34. A method for fabrication of graphene oxide nanoribbons from graphene oxide wrinkles10.1021/jp9079298 ↗
35. Thermally reduced graphene oxide films as flexible lateral heat spreaders10.1039/C4TA02693D ↗
36. Enhancing thermoelectric properties of organic composites through hierarchical nanostructures10.1038/srep03448 ↗
37. Synthesis of fluorinated graphene with tunable degree of fluorination10.1016/j.carbon.2012.07.026 ↗
38. The reduction of graphene oxide10.1016/j.carbon.2011.11.010 ↗
39. One-pot synthesis of graphene/hydroxyapatite nanorod composite for tissue engineering10.1016/j.carbon.2013.09.016 ↗
40. One-pot green synthesis, characterizations, and biosensor application of self-assembled reduced graphene oxide-gold nanoparticle hybrid membranes10.1039/c3tb21270j ↗
41. The role of alkaline phosphatase in mineralization10.1097/BCO.0b013e3282630851 ↗
42. How useful is SBF in predicting in vivo bone bioactivity?10.1016/j.biomaterials.2006.01.017 ↗
43. Modern biomaterials: a review—bulk properties and implications of surface modifications
44. FTIR spectroscopic, thermal and XRD characterization of hydroxyapatite from new natural sources10.1016/j.saa.2011.07.036 ↗
45. Noncovalent functionalization of graphene with end-functional polymers10.1039/b919074k ↗
46. Improving the mechanical properties of graphene oxide based materials by covalent attachment of polymer chains10.1016/j.carbon.2012.09.046 ↗
47. FTIR and XPS studies of bioactive silica based glasses10.1016/j.jnoncrysol.2003.09.013 ↗
48. A new synthesis route to high surface area sol gel bioactive glass through alcohol washing: a preliminary study10.4161/biom.24288 ↗
49. Bioactive coating with hierarchical double porous structure on titanium surface formed by two-step microarc oxidation treatment10.1016/j.surfcoat.2014.04.061 ↗
50. Biomimetic apatite mineralization mechanisms of mesoporous bioactive glasses as probed by multinuclear 31P 29Si, 23Na and 13C solid-State NMR10.1021/jp105408c ↗
51. The use of carbon nanotubes to reinforce 45S5 bioglass-based scaffolds for tissue engineering applications10.1155/2013/465086 ↗
52. New generation poly(ε-caprolactone)/gel-derived bioactive glass composites for bone tissue engineering: part I. Material properties10.1016/j.msec.2015.06.020 ↗