Role of liquid membrane phenomenon in the biological actions of thioridazine
Source abstract
Abstract
Role of surface activity in the mechanism of action of thioridazine (THR) has been studied. THR has been shown to generate liquid membrane it self and also in association with the relevant membrane lipids, sphingomyelin and cholesterol in series with a supporting membrane. Transport of relevant biogenic amines e.g. dopamine, nor-adrenaline, adrenaline, serotonin, gamma amino butyric acid (GABA) and glutamic acid and ions viz. sodium, potassium, and calcium has been studied in the presence of liquid membranes generated by THR and THE in association with sphingomyelin-cholesterol. The data on modifications in the permeability of relevant biogenic amines and ions indicate that the liquid membranes generated by THR may contribute to the mechanism of action of THR.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Neuroscience and Neuropharmacology Research · Lipid Membrane Structure and Behavior · Molecular Sensors and Ion Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. R.E. Kesting, A. Vincent, J. Eberlin, Osw R & W Report, 1964, p. 117.
2. R.E. Kesting, OSW Patent Application SAL (1965), p. 830.
3. Kesting · J. Colloid Interface Sci. · 1968 · 28 · 15610.1016/0021-9797(68)90217-8 ↗
4. Srivastava · 2002
5. Srivastava · 2003
6. Zografi · 1975 · 297
7. Florence · Adv. Colloid. Interface. Sci. · 1968 · 2 · 11510.1016/0001-8686(68)85002-X ↗
8. Guth · Int. Rev. Neurobiol. · 1964 · 7 · 23110.1016/S0074-7742(08)60269-X ↗
9. Felmeister · J. Pharm. Sci. · 1972 · 61 · 15110.1002/jps.2600610202 ↗
10. Attwood · J. Pharm. Pharmacol. · 1978 · 30 · 17610.1111/j.2042-7158.1978.tb13192.x ↗
11. Attwood · J. Pharm. Pharmacol. · 1972 · 24 · 75110.1111/j.2042-7158.1972.tb09107.x ↗
12. Attwood · J. Pharm. Pharmacol. · 1976 · 28 · 40710.1111/j.2042-7158.1976.tb04643.x ↗
13. Ritchie · Annu. Rev. Pharmacol. · 1966 · 6 · 40510.1146/annurev.pa.06.040166.002201 ↗
14. Vilallonga · J. Pharm. Sci. · 1980 · 69 · 10210.1002/jps.2600690132 ↗
15. Hellenbrecht · Naunyn Schmiedebergs Arch. Pharmacol. · 1973 · 277 · 21110.1007/BF00501161 ↗
16. Sitsen · Pharm. Weekbl. · 1972 · 107 · 69
17. Thoma · Pharm. Acta Helv. · 1984 · 59 · 213
18. Attwood · J. Pharm. Sci. · 1974 · 63 · 98810.1002/jps.2600630649 ↗
19. Srivastava · Adv. Colloid Interface Sci. · 1984 · 20 · 13110.1016/0001-8686(84)89002-8 ↗
20. Srivastava · J. Phys. Chem. · 1981 · 85 · 14810.1021/j150610a035 ↗
21. Srivastava · J. Pharm. Sci. · 1983 · 72 · 59910.1002/jps.2600720606 ↗
22. Srivastava · Colloids Surf. · 1985 · 14 · 110.1016/0166-6622(85)80036-6 ↗
23. Srivastava · Colloids Surf. · 1986 · 19 · 8310.1016/0166-6622(86)80038-5 ↗
24. Srivastava · J. Membr. Sci. · 1991 · 58 · 21110.1016/S0376-7388(00)82457-6 ↗
25. Nagappa · J. Membr. Sci. · 2003 · 211 · 34910.1016/S0376-7388(02)00431-3 ↗
26. Nagappa · Colloids Surf. B: Biointer. · 2003 · 32 · 16910.1016/S0927-7765(03)00156-5 ↗
27. Nagappa · J Colloid Interface Sci. · 2004 · 271 · 41610.1016/j.jcis.2003.12.014 ↗
28. Pandi · Colloids Surf. B: Biointer. · 2004 · 35 · 24310.1016/j.colsurfb.2004.03.006 ↗
29. Janssen · Int. J. Neuropsychiatry · 1967 · 3 · 10
30. Palm · 1970 · 188
31. Ahyayauch · J. Colloid Interface Sci. · 2002 · 256 · 28410.1006/jcis.2002.8690 ↗
32. Ahyayauch · Therapie · 1999 · 54 · 585
33. Tharmapathy · Biochem. Pharmacol. · 2000 · 60 · 126710.1016/S0006-2952(00)00445-7 ↗
34. Silverstein · 1981
35. British Pharmacopoeia. Department of Health and Social Services for northern Ireland, 1993, pp. 230.
36. 1979
37. Mouritsen · Chem. Phys. Lipids · 1994 · 73 · 310.1016/0009-3084(94)90171-6 ↗
38. Mouritsen · Biochim. Biophys. Acta · 1997 · 1331 · 23510.1016/S0304-4157(97)00008-7 ↗
39. Truedell · Anestheology · 1977 · 46 · 510.1097/00000542-197701000-00003 ↗
40. Attwood · Adv. Colloid. Interface Sci. · 1995 · 55 · 27110.1016/0001-8686(94)00228-5 ↗
41. Seaman · Biochem. Pharmacol. · 1963 · 12 · 118110.1016/0006-2952(63)90093-5 ↗
42. Sherwood · Ind. Eng. Chem. Fund. · 1967 · 6 · 210.1021/i160021a001 ↗
43. Singh · Indian J. Biochem. Biophys. · 1991 · 28 · 34
44. Srivastava · Indian. J. Chem. · 1992 · 31 · 533
45. Skarsfeldt · Life Sci. · 1988 · 42 · 103710.1016/0024-3205(88)90558-9 ↗
46. Zorumski · Neurosci. Lett. · 1988 · 92 · 8610.1016/0304-3940(88)90747-1 ↗
47. Hardman · 1996
48. Petty · Neuropharmacology · 1984 · 23 · 7310.1016/0028-3908(84)90219-3 ↗
49. Thorgeirsson · Biochem. Biophys. Res. Commun. · 1984 · 121 · 65710.1016/0006-291X(84)90232-8 ↗
50. Teisseyre · Biochem. Pharmacol. · 2003 · 65 · 55110.1016/S0006-2952(02)01561-7 ↗