journal article·2023-03-14

Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer

Chunhua Zhao, Zekun Liu, Chia-Che Chang, Yi-Chia Chen, Qize Zhang, Xiao-Dong Zhang, Chrysafis Andreou, Jiadong Pang, Ze-Xian Liu, Di-Yan Wang, Moritz F. Kircher, Jiang Yang

ACS Nano· Volume 17· Issue 5
Publisher page

Abstract

Triple-negative breast cancer (TNBC) is considered more aggressive with a poorer prognosis than other breast cancer subtypes. Through systemic bioinformatic analyses, we established the ferroptosis potential index (FPI) based on the expression profile of ferroptosis regulatory genes and found that TNBC has a higher FPI than non-TNBC in human BC cell lines and tumor tissues. To exploit this finding for potential patient stratification, we developed biologically amenable phototheranostic iron pyrite FeS 2 nanocrystals (NCs) that efficiently harness near-infrared (NIR) light, as in photovoltaics, for multispectral optoacoustic tomography (MSOT) and photothermal ablation with a high photothermal conversion efficiency (PCE) of 63.1%. Upon NIR irradiation that thermodynamically enhances Fenton reactions, dual death pathways of apoptosis and ferroptosis are simultaneously triggered in TNBC cells, comprehensively limiting primary and metastatic TNBC by regulating p53, FoxO, and HIF-1 signaling pathways and attenuating a series of metabolic processes, including glutathione and amino acids. As a unitary phototheranostic agent with a safe toxicological profile, the nanocrystal represents an effective way to circumvent the lack of therapeutic targets and the propensity of multisite metastatic progression in TNBC in a streamlined workflow of cancer management with an integrated image-guided intervention.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Ferroptosis and cancer prognosis · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Department of Chemistry, Tunghai University, Taichung 40704, Taiwan

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300354, China

Department of Electrical and Computer Engineering, University of Cyprus, Nicosia 1678, Cyprus

Funding

State Key Laboratory of Oncology in South China · National Cancer Institute · Pershing Square Sohn Cancer Research Alliance · Ministry of Science and Technology of the People's Republic of China · Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program · Government of Guangdong Province · National Institute of Biomedical Imaging and Bioengineering · Tunghai University · Parker Institute for Cancer Immunotherapy · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Ministry of Science and Technology, Taiwan · Sun Yat-sen University Cancer Center

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