journal article·2026-06-30Open access

Steady‐State and Dynamic Behavior of Geometry‐Tunable Microfluidic Passive Flow Regulators

Huy Hoang Vu, Tran Vy Khanh Vo, Hafiz Muhammad Musharaf, Haotian Cha, Nam‐Trung Nguyen

Abstract

ABSTRACT Passive flow regulators enable autonomous, stable flow control without external electronics or active feedback. However, their dynamic response remains insufficiently investigated, limiting their potential integration into time‐dependent fluidic circuits. Here, we present a reduced‐order analytical framework based on an electrical analogy, along with systematic experimental characterization of a passive microfluidic flow regulator inspired by a fluidic transistor architecture. Devices with channel widths ranging from 300 to 700 µm were fabricated using soft lithography to examine how geometry affects both the regulated flow rate and its transient response. Steady‐state characterization revealed nonlinear flow–pressure relationships, with narrower channels exhibiting higher fluidic resistance and earlier onset of flow saturation. Dynamic characterization showed dominant first‐order low‐pass behavior governed by fluid‐structure interactions within the elastofluidic network. The effective bandwidth decreases with increasing channel width, revealing a fundamental trade‐off between throughput and transient response. Experimental data agreed well with the developed reduced‐order fluidic resistance‐capacitance model. Thus, geometry‐dependent transient dynamics can be captured using compact, physically interpretable parameters without relying on a complex fluid‐structure‐interaction model. These findings establish quantitative geometry‐dynamics relationships and provide practical design guides for integrating compliant flow‐controlling elements into microfluidic circuits, lab‐on‐a‐chip, and autonomous microfluidic systems with reliable and predictable dynamic performance.
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Research context

OpenAlex topics: Microfluidic and Capillary Electrophoresis Applications · Micro and Nano Robotics · Plasma and Flow Control in Aerodynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Queensland Quantum and Advanced Technologies Research Institute Griffith University Nathan Queensland Australia

School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore Singapore

School of Engineering and Built Environment Griffith University Nathan Queensland Australia

References (35)

Show source-provided references
1. 10.1038/nrd.2017.23210.1038/nrd.2017.232 ↗
2. 10.1038/nchem.175310.1038/nchem.1753 ↗
3. 10.1038/nrg.2017.1510.1038/nrg.2017.15 ↗
4. 10.1016/j.cell.2015.05.00210.1016/j.cell.2015.05.002 ↗
5. Microfluidic Biochips for Single‐Cell Isolation and Single‐Cell Analysis of Multiomics and Exosomes10.1002/advs.202401263 ↗
6. 10.1039/b821803j10.1039/b821803j ↗
7. Integrated Microfluidic DNA Storage Platform with Automated Sample Handling and Physical Data Partitioning10.1021/acs.analchem.2c02667 ↗
8. 10.1002/(SICI)1522‐2683(20000101)21:1<27::AID‐ELPS27>3.0.CO;2‐C10.1002/(SICI)1522‐2683(20000101)21:1<27::AID‐ELPS27>3.0.CO;2‐C ↗
9. Nguyen N. T. · 2011
10. 10.1039/C5LC01159K10.1039/C5LC01159K ↗
11. Nguyen N. T. · 2019
12. Micro Elastofluidics: Elasticity and Flexibility for Efficient Microscale Liquid Handling10.3390/mi11111004 ↗
13. Materials for Diabetes Therapeutics10.1002/adhm.201200037 ↗
14. 10.3390/app1024885810.3390/app10248858 ↗
15. 10.1038/nature1311810.1038/nature13118 ↗
16. 10.1038/nature0506410.1038/nature05064 ↗
17. Flow Control in a Laminate Capillary‐Driven Microfluidic Device10.1039/D0AN02279A ↗
18. A Microfluidic Transistor for Automatic Control of Liquids10.1038/s41586-023-06517-3 ↗
19. Passive Micro Elastofluidic Controller for Constant Flow Rate
20. Fluidic–Electric Analogy for Design and Operation of Microfluidic Systems10.1039/D3LC00265A ↗
21. 10.1039/C2LC20799K10.1039/C2LC20799K ↗
22. 10.1039/c1lc20387h10.1039/c1lc20387h ↗
23. Microfluidic Automation Using Elastomeric Valves and Droplets: Reducing Reliance on External Controllers10.1002/smll.201200456 ↗
24. 10.1039/b518362f10.1039/b518362f ↗
25. A Robust Normally Closed Pneumatic Valve for Integrated Microfluidic Flow Control10.3390/mi16010034 ↗
26. Nonlinear Microfluidics: Device Physics, Functions, and Applications10.1039/D0LC01120G ↗
27. 10.1016/j.sna.2026.11787010.1016/j.sna.2026.117870 ↗
28. 10.1021/acs.analchem.5c0236710.1021/acs.analchem.5c02367 ↗
29. Periodic Flows in Microfluidics10.1002/smll.202404685 ↗
30. 10.1088/0960‐1317/20/3/03502610.1088/0960‐1317/20/3/035026 ↗
31. 10.1016/j.ces.2017.12.04510.1016/j.ces.2017.12.045 ↗
32. Nguyen N.‐T. M. · 2013
33. Kelly P. · 2013 · 188
34. Altabey W. A. · 2023
35. System Identification: Theory for the User (Second Edition): Lennart Ljung; Prentice‐Hall, Englewood Cliffs, NJ, 1999. ISBN 0‐13‐656695‐210.1016/S0005-1098(01)00214-X ↗