DataVXACS Biomaterials Science & EngineeringPaper
journal article·2025-11-10Open access

Release, Transfer, Fold: Using a Silicone Adhesive for On-Demand 3D Tissue Engineering

Doris Roth, Benedetta Zampa, Romina Augustin, Daara Payandehjoo, Giancarlo Porcella, Ayşe Tuğçe Şahin, Anne M. van der Does, Janna C. Nawroth

ACS Biomaterials Science & Engineering· Volume 11· Issue 11
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Source abstract

Abstract

Conventional cell culture substrates are flat and rigid, locking cells in a permanent and unphysiological geometry. Advanced tissue culture models that emulate the dynamic and 3D environments of organs remain challenging to generate. Here, we establish flexible silicone adhesive films as versatile substrates that enable the on-demand release, transfer, and folding of cultured 2D tissues into 3D geometries. We rolled primary epithelial cultures into tubes, assembled cuboidal structures, and transferred primary endothelial cultures between culture environments for coculturing. Our approach provides an easy-to-implement platform for dynamic geometrical designs in tissue engineering.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Helmholtz Pioneer Campus

Helmholtz Zentrum München

Institute of Biological and Medical Imaging, Bioengineering Center

Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health

Technical University of Munich

Comprehensive Pneumology Center Munich

German Center for Lung Research (DZL)

Faculty of Engineering Sciences

University of Heidelberg

PulmoScience Lab, Department of Pulmonology

Leiden University Medical Center

Funding

HORIZON EUROPE European Research Council

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