DataVXACS Biomaterials Science & EngineeringPaper
journal article·2024-11-11

Natural Phycocyanin/Paclitaxel Micelle Delivery of Therapeutic P53 to Activate Apoptosis for HER2 or ER Positive Breast Cancer Therapy

Ling-Kun Zhang, Yuan Li, Limin Zhai, Yunzhi Tang, Yuxuan Jiao, Yitong Mei, Runcai Yang, Rong You, Liang Yin, He Ni, Jian Ge, Yan-Qing Guan

ACS Biomaterials Science & Engineering· Volume 10· Issue 11
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Source abstract

Abstract

The P53 gene is commonly mutated in breast cancer, protein based the gene as anticancer drugs could provide efficient and stable advantages by restoring the function of the wild-type P53 protein. In this study, we describe the creation and utilization of a micelle composed by natural phycocyanin and paclitaxel and grafting anti-HER2 (PPH), which effectively packages and transports recombinant P53 protein with anti-ER (PE), resulting in a new entity designated as PE@PPH, to address localization obstacles and modify cellular tropism to the cell membrane or nucleus. The results indicate that PE@PPH has strong antitumor properties, even at low doses of PTX both in vitro and in vivo . These findings suggest that PE@PPH could be an enhancing micelle for delivering therapeutic proteins and promoting protein functional recovery, particularly in addressing the challenges posed by tumor heterogeneity in breast cancer.
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Research context

OpenAlex topics: Algal biology and biofuel production · Plant tissue culture and regeneration · Microtubule and mitosis dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Life Science

South China Normal University

School of Engineering

Westlake University

Institute of Advanced Technology, Westlake Institute for Advanced Study

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center

Sun Yat-sen University

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, Guangdong Provincial Key Laboratory of Laser Life Science, Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics

Funding

Science and Technology Planning Project of Guangdong Province · China Postdoctoral Science Foundation · State Key Laboratory of Ophthalmology · National Natural Science Foundation of China · Scientific and Technological Planning Project of Guangzhou City · Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme

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