journal article·2021-06-14

Ordered Fibril Arrays in Osteons Promote the Multidirectional Nanodeflection of Cracks: In Situ AFM Imaging

Tianbao Qian, Xiangxin Chen, Fei Hang, Jian Zhuang, Xiaofeng Chen

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Abstract

The high fracture resistance of cortical bone is not completely understood across its complex hierarchical structure, especially on micro- and nanolevels. Here, a novel in situ bending test combined with atomic force microscopy (AFM) is utilized to assess the micro-/nanoscale failure behavior of cortical bone under the external load. Unlike the smoother crack path in the transverse direction, the multilevel composite material model endows the longitudinal direction to show multilevel Y-shaped cracks with more failure interfaces for enhancing the fracture resistance. In the lamellae, the nanocracks originating from the interfibrillar nanointerface deflect multidirectionally at certain angles related to the periodic ordered arrangement of the mineralized collagen fibril (MCF) arrays. The ordered MCF arrays in the lamellae may use the nanodeflection of the dendritic nanocracks to adjust the direction of the crack tip, which subsequently reaches the interlamellae to sharply deflect and finally form a zigzag path. This work provides an insight into the relationship between the structure and the function of bone at a multilevel under load, specifically the role of the ordered MCF arrays in the lamellar structure.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Bone health and osteoporosis research · Calcium Carbonate Crystallization and Inhibition

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong, P. R. China

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P. R. China

Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, P. R. China

Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China

Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P. R. China

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, Guangdong, P. R. China

Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P. R. China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · Guangzhou Science and Technology Program key projects · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Guangdong Province

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