Boronic Acid Copolymers for Direct Loading and Acid-Triggered Release of Bis-T-23 in Cultured Podocytes
Source abstract
Abstract
We report an acid-reversible linker for triggered release of Bis-T-23, an experimental small molecule drug for kidney disease treatment that restores podocyte morphology during disease. Bis-T-23 contains catechols, which form an acid-reversible, covalent boronate ester bond with boronic acids. We synthesized phenylboronic acid-containing polymers using reversible addition-fragmentation chain transfer polymerization that were able to directly load and solubilize Bis-T-23. Because of the reversibility of the boronic ester bond, drug was released in its native form in a pH-dependent manner. The polymers rapidly trafficked into acidic compartments and did not exhibit cytotoxicity, and polymer-drug conjugates successfully delivered Bis-T-23 into cultured podocytes.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Renal Diseases and Glomerulopathies · Dialysis and Renal Disease Management · Bipolar Disorder and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, 3720 15th Avenue NE, Seattle, Washington 98195, United States
Department of Medicine, Division of Nephrology, School of Medicine, University of Washington, 750 Republican Street, E-179, Seattle, Washington 98109, United States
Funding
Ministry of Education of the People's Republic of China · National Institute of Diabetes and Digestive and Kidney Diseases · Division of Graduate Education · U.S. Department of Defense · National Institute on Aging
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