DataVXACS Biomaterials Science & EngineeringPaper
journal article·2021-09-13

Incorporation of Layered Rectorite into Biocompatible Core–Sheath Nanofibrous Mats for Sustained Drug Delivery

Hu Tu, Fangfang Dai, Gu Cheng, Mengqin Yuan, Xue Zhou, Yanqing Wang, Ruquan Zhang, Yajing Zheng, Yanxiang Cheng, Hongbing Deng

ACS Biomaterials Science & Engineering· Volume 7· Issue 9
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Source abstract

Abstract

Searching for drug carries with controlled release and good biocompatibility has always been one of the research hotspots and difficulties. Herein, core–sheath nanofibrous mats (NFs) consisting of biocompatible poly(ethylene oxide) (PEO, core) and poly(l-lactic acid) (PLLA, sheath) for drug delivery were fabricated via coaxial electrospinning strategy. The nontoxic layered silicate rectorite (REC) with 0.5–1 wt % amount was introduced in the sheath for sustained drug delivery. Layered REC could be intercalated with PLLA macromolecule chains, leading to the densified structure for loading and keeping doxorubicin hydrochloride (DOX) while reversibly capturing and releasing DOX to delay the drug migration due to its high cation activity. The addition of REC in NFs could delay the initial burst release of DOX and prolong the residence time from 12 to 96 h. Moreover, DOX-loaded core–sheath NFs had in vitro culture with strong antitumor activity, which was confirmed by cytotoxicity results and live and dead assay. HepG2 tumor-bearing xenograft further demonstrated the tumor-suppression effect and the excellent safety of the DOX-loaded core–sheath NFs in vivo. The constructed NFs as drug carriers showed great potential in the local treatment of solid tumors.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hubei Key Laboratory of Biomass Resource Chemistry and Environmental Biotechnology, Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy, Hubei Engineering Center of Natural Polymers-Based Medical Materials, School of Resource and Environmental Science, Wuhan University, Wuhan 430079, China

State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Wuhan Textile University, Wuhan 430200, China

Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Hubei-MOST KLOS & KLOBME, Department of Oral and Maxillofical Trauma and Plastic Surgery, Wuhan University Stomatological Hospital, Wuhan University, Wuhan 430079, China

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Funding

National Natural Science Foundation of China · Natural Science Foundation for Distinguished Young Scholars of Hubei Province of China · Hubei Provincial Key Research and Development Project

References (55)

Show source-provided references
1. 10.1007/s12274-017-1934-310.1007/s12274-017-1934-3 ↗
2. 10.1021/acsami.5b0212910.1021/acsami.5b02129 ↗
3. 10.1021/acsabm.8b0045910.1021/acsabm.8b00459 ↗
4. 10.1016/j.apsusc.2015.02.03710.1016/j.apsusc.2015.02.037 ↗
5. 10.1016/j.jconrel.2005.08.00610.1016/j.jconrel.2005.08.006 ↗
6. 10.1021/acsami.5b0600710.1021/acsami.5b06007 ↗
7. 10.1021/acsabm.9b0011910.1021/acsabm.9b00119 ↗
8. 10.1016/j.memsci.2015.05.04010.1016/j.memsci.2015.05.040 ↗
9. 10.1021/acsnano.8b0603210.1021/acsnano.8b06032 ↗
10. 10.1021/nn504573u10.1021/nn504573u ↗
11. 10.1016/j.jcis.2017.08.07110.1016/j.jcis.2017.08.071 ↗
12. 10.1016/j.actbio.2006.02.00510.1016/j.actbio.2006.02.005 ↗
13. 10.1016/j.colsurfb.2011.06.00410.1016/j.colsurfb.2011.06.004 ↗
14. 10.1016/j.addr.2012.09.02610.1016/j.addr.2012.09.026 ↗
15. 10.1002/adfm.20180285210.1002/adfm.201802852 ↗
16. 10.1016/j.biomaterials.2015.02.07610.1016/j.biomaterials.2015.02.076 ↗
17. 10.1039/C7TB01825H10.1039/C7TB01825H ↗
18. 10.1021/acsabm.9b0030810.1021/acsabm.9b00308 ↗
19. 10.1021/ja010720l10.1021/ja010720l ↗
20. 10.1039/C7PY00223H10.1039/C7PY00223H ↗
21. 10.1016/j.carbpol.2009.09.01210.1016/j.carbpol.2009.09.012 ↗
22. 10.1016/j.cej.2007.10.00910.1016/j.cej.2007.10.009 ↗
23. 10.1016/j.jhazmat.2009.06.05310.1016/j.jhazmat.2009.06.053 ↗
24. 10.1039/C8TB01085D10.1039/C8TB01085D ↗
25. 10.1016/j.carbpol.2016.05.04510.1016/j.carbpol.2016.05.045 ↗
26. 10.1016/j.carbpol.2006.08.02510.1016/j.carbpol.2006.08.025 ↗
27. 10.1016/j.apsusc.2017.07.15910.1016/j.apsusc.2017.07.159 ↗
28. 10.1016/j.ijpharm.2015.07.06310.1016/j.ijpharm.2015.07.063 ↗
29. 10.1039/C4CS00226A10.1039/C4CS00226A ↗
30. 10.1016/j.actbio.2015.08.00310.1016/j.actbio.2015.08.003 ↗
31. 10.1039/C5BM00414D10.1039/C5BM00414D ↗
32. 10.1080/09205063.2019.170060010.1080/09205063.2019.1700600 ↗
33. 10.1039/c3tb20406e10.1039/c3tb20406e ↗
34. 10.1039/C9BM01986C10.1039/C9BM01986C ↗
35. 10.1039/C8BM00693H10.1039/C8BM00693H ↗
36. 10.1016/j.biomaterials.2014.12.00610.1016/j.biomaterials.2014.12.006 ↗
37. 10.1039/c3ta12390a10.1039/c3ta12390a ↗
38. 10.1016/j.cplett.2016.02.06510.1016/j.cplett.2016.02.065 ↗
39. 10.1021/acssuschemeng.5b0040410.1021/acssuschemeng.5b00404 ↗
40. 10.1016/j.actbio.2016.03.01310.1016/j.actbio.2016.03.013 ↗
41. 10.1016/j.jcis.2019.03.02410.1016/j.jcis.2019.03.024 ↗
42. 10.1002/adhm.20130023510.1002/adhm.201300235 ↗
43. 10.1016/j.carbpol.2012.10.06010.1016/j.carbpol.2012.10.060 ↗
44. 10.1039/c3tb20636j10.1039/c3tb20636j ↗
45. 10.1002/adhm.20120043410.1002/adhm.201200434 ↗
46. 10.1021/acsabm.8b0002310.1021/acsabm.8b00023 ↗
47. 10.1016/j.clay.2014.01.00610.1016/j.clay.2014.01.006 ↗
48. 10.1016/j.jconrel.2005.09.01110.1016/j.jconrel.2005.09.011 ↗
49. 10.1080/09205063.2020.174096310.1080/09205063.2020.1740963 ↗
50. 10.1016/j.msec.2016.08.05410.1016/j.msec.2016.08.054 ↗
51. 10.1021/cm049580f10.1021/cm049580f ↗
52. 10.1016/j.memsci.2012.09.06210.1016/j.memsci.2012.09.062 ↗
53. 10.1016/j.ijbiomac.2018.12.17810.1016/j.ijbiomac.2018.12.178 ↗
54. 10.1016/j.ijpharm.2012.01.01210.1016/j.ijpharm.2012.01.012 ↗
55. 10.1016/j.ijbiomac.2020.02.06710.1016/j.ijbiomac.2020.02.067 ↗