DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-11-11

Antioxidant Nanomedicine Protects against Ionizing Radiation-Induced Life-Shortening in C57BL/6J Mice

Chitho P. Feliciano, Yukio Nagasaki

ACS Biomaterials Science & Engineering· Volume 5· Issue 11
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Source abstract

Abstract

This study examined a new redox nanoparticle (RNPN) for its ability to protect mice from the life-shortening effect of radiation. A single dose of RNPN was injected subcutaneously into mice 3 or 24 h before whole-body irradiation. Kaplan–Meier survival analysis showed that RNPN given 24 h before whole-body irradiation protected mice against radiation-induced mortality. Histological evaluation of the bone marrow showed that the probable cause of sporadic deaths was bone marrow aplasia. Furthermore, analysis of blood biomarkers revealed abnormalities in the irradiated control group. Such symptoms/indicators of poor health were reduced in RNPN-treated mice.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Effects of Radiation Exposure · Radiation Therapy and Dosimetry · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan

Radiation Research Center (RRC), Atomic Research Division, Philippine Nuclear Research Institute, Department of Science and Technology (PNRI-DOST), Commonwealth Avenue, Diliman, Quezon City 1101, Philippines

Master’s School of Medical Sciences, Graduate School of Comprehensive Human Sciences, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan

Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, Japan

Funding

Ministry of Education, Culture, Sports, Science and Technology · Philippine Nuclear Research Institute

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