DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-04-08Open access

Hydroxypropylcellulose Coating to Improve Graft-to-Bone Healing for Anterior Cruciate Ligament Reconstruction

Jianjun Yang, Yu Dong, Jianguang Wang, Chen Chen, Yuchang Zhu, Yang Wu, Peng Zhang, Tianwu Chen, Weifeng Zhou, Peiyi Wu, Nguyen T. K. Thanh, Ngoc Quyên Trân, Jun Chen, Shiyi Chen

ACS Biomaterials Science & Engineering· Volume 5· Issue 4
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Source abstract

Abstract

An anterior cruciate ligament (ACL) injury is one of the most common injuries in sports, and ACL reconstruction with an artificial ligament is a good treatment for quick recovery. However, current artificial ligaments made of polyethylene terephthalate (PET) are still associated with some problems due to the hydrophobic nature and low biological induction activity of PET. Many efforts have been used to improve the biocompatibility of PET in recent years, and our previous work has shown that surface modification is an effective strategy. Here, a hydroxypropylcellulose (HPC) coating was applied on the surface of a PET artificial ligament order to improve its biocompatibility. The effects of the HPC coating on PET artificial ligament graft-bone healing was investigated in vitro using bone marrow stromal cells (BMSCs), fibroblasts, and RSC-364 cells as well as in vivo in a beagle dog model of ACL reconstruction. HPC was coated successfully on the PET and significantly promoted cell growth, adhesion, and capability of osteogenic differentiation compared to the PET graft without HPC coating. In vivo, the HPC coating significantly enhanced ligament tissue regeneration. Moreover, higher expression of some bone-formation- and ligament-tissue-regeneration-contributing proteins and cell factors, such as COL1, BMP-7, COL3, OCN, RUNX2, TGF-β1, and VEGF, was observed on the HPC-coated PET artificial ligament in comparison with the pure PET artificial ligament. In conclusion, HPC coating can significantly improve the cytocompatibility and graft-to-bone healing of a PET artificial ligament for ACL reconstruction.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Knee injuries and reconstruction techniques · Polymer Surface Interaction Studies · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics, Tenth People’s Hospital of Tongji University, Shanghai 200072, People’s Republic of China

Fudan University Sports Medicine Center and Department of Sports Medicine and Arthroscopy Surgery, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China

Sports Medicine Center, Shanghai Six People’s Hospital and Six People’s Hospital Affiliated with Shanghai Jiaotong University, Shanghai 200233, People’s Republic of China

Department of Orthopaedics, Cixi People’s Hospital and Cixi Hospital Affiliated with Wenzhou Medical University, Ningbo 315300, People’s Republic of China

Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China

Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, United Kingdom

Institute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City, 700000, Vietnam

Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, 700000, Vietnam

Funding

National Natural Science Foundation of China · Air Force Office of Scientific Research · Science and Technology Commission of Shanghai Municipality · Engineering and Physical Sciences Research Council · Royal Society · Ministry of Science and Technology of the People's Republic of China · Key Clinical Medicine Center of Shanghai · Zhejiang Province · Sanming Project of Medicine in Shenzhen · CAS Key Laboratory of Nano-Bio Interface · Clinical Medicine Expert Team for Suzhou

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