DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-02-11

Loquat-Inspired Janus Drug Delivery System for Flexible and Robust Tumor Targeting Therapy

Yu Liu, Chaochao Wei, Long Huang, Weizhu Liu, Jiaqi Lin, Leifeng Chen, Yalan Yang, Ping Hu, Anwen Liu, Xiaolei Wang

ACS Biomaterials Science & Engineering· Volume 5· Issue 2
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Source abstract

Abstract

With the inspiration of the shape of the loquat fruit, here, we developed a similarly shaped Janus carrier. This peculiar gold rod-partially exposed structure not only significantly increased the drug loading capability but also improved its infrared response efficiency. A better effect of drug-photothermal treatment thus could be realized. With the aid of an external 3D printed drug guiding device, this carrier could accurately reach different affected areas. The subsequent infrared triggered multiple tumor therapy, thus, could be conducted in the designated location. The corresponding experimental results demonstrated the reliability, flexibility, and biocompatibility of the proposed drug delivery system for two different tumor targeting treatments.
Source: openalex_inverted_index · Quality: baseline

Research context

BiomaterialsMaterials processing

OpenAlex topics: Nanoplatforms for cancer theranostics · 3D Printing in Biomedical Research · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Second Affiliated Hospital of Nanchang University, NanChang, No. 1 minde Road, Donghu District 330006, China

College of Chemistry, NanChang University, Hong Gu Tan New District, 1299 XueFu Road, NanChang, 330088, China

The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, NanChang University, Hong Gu Tan New District, 1299 XueFu Road, NanChang, 330088, China

Funding

National Natural Science Foundation of China · Science Foundation of Jiangxi Provincial Department of Education

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