DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-02-11

Rapid Coating Process Generates Omniphobic Dentures in Minutes to Reduce C. albicans Biofouling

Anna Waterhouse, Daniel C. Leslie, Kayla Lightbown, Daniel Antonoff, Shanda Lightbown, Nikolaos Dimitrakakis, Julia B. Hicks-Berthet, Cheyene N. Leslie, Michael Super, Donald E. Ingber, Marc B. Ackerman

ACS Biomaterials Science & Engineering· Volume 5· Issue 2
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Source abstract

Abstract

Localized infections caused by biofilm formation on dentures pose a serious health risk for patients, especially the elderly, as they can lead to complications such as pneumonia. Daily enzymatic denture cleaners do not fully prevent biofilm formation on dentures. Here we developed a rapid coating process to apply a liquid repellent surface to dentures in ∼5 min and demonstrated a significant 225-fold reduction of Candida albicans adhesion over 6 days, compared to uncoated dentures. This rapid coating process could be applied to dentures and other dental devices chair-side and allow the research community to quickly and easily generate ominphobic surfaces.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Antifungal resistance and susceptibility · Antimicrobial agents and applications · Fungal Infections and Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, Boston, Massachusetts 02115, United States

Vascular Biology Program, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States

Department of Dentistry, Boston Children’s Hospital, Boston, Massachusetts 02115, United States

Department of Developmental Biology, School of Dental Medicine, Harvard University, Boston, Massachusetts, United States

Funding

Boston Children's Hospital · Wyss Institute for Biologically Inspired Engineering, Harvard University

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