journal article·2019-09-09

Nanomedicine Fabricated from A Boron-dipyrromethene (BODIPY)-Embedded Amphiphilic Copolymer for Photothermal-Enhanced Chemotherapy

Jie Shen, Qiwen Wang, Yuanyuan Lv, Jingyin Dong, Guida Xuan, Jie Yang, Dan Wu, Jiong Zhou, Guocan Yu, Guping Tang, Xiao Li, Feihe Huang, Xiaoyuan Chen

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Abstract

To overcome the shortcomings of chemotherapy including side effects and uncontrollable release, as well as to increase the therapeutic efficacy, a diblock copolymer (mPEG-b-PLA-BODIPY) was constructed containing a NIR absorbing boron-dipyrromethene (BODIPY) tail, a hydrophobic polylactide (PLA) segment, and a hydrophilic poly(ethylene glycol) (PEG) segment. The nanoparticles self-assembled from mPEG-b-PLA-BODIPY with a core–shell structure were utilized to load docetaxel (DTX) in the core through hydrophobic interaction. Tailored drug release and high tumor penetration of the nanomedicine were realized by fully taking advantage of photothermal effect and the enhanced penetration and retention effect, facilitating enhanced therapeutic performance and reducing undesirable side effects. In vivo antitumor studies demonstrate that photothermal-enhanced chemotherapy effectively suppresses tumor progression, while systemic toxicity and side effects of DTX are remarkably decreased benefiting from rational design. This pioneering example provides a blueprint for the next generation of polymeric delivery vehicles integrating novel theranostic functions.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Medicine, Zhejiang University City College, Hangzhou 310015, P. R. China

Heart and Vascular Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003 Zhejiang, P. R. China

State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China

Department of Chemistry, Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310027, P. R. China

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States

Women’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006 Zhejiang, China

The Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006 Zhejiang, China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China

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