Empowering Healthcare with Phage Display Technology
Source abstract
Abstract
Phage display technology, a molecular screening tool introduced in 1985, facilitates the display of peptides or proteins on phage surfaces to identify high-affinity ligands. Phage display has enabled the identification of peptides that enhance biomaterial biocompatibility, support stem cell proliferation and differentiation, and facilitate targeted drug delivery. Additionally, it has been utilized in bacterial detection, disease biomarker identification, and targeted therapies, including crossing the blood-brain barrier for improved cancer treatments. Despite challenges such as peptide stability and immunogenicity, ongoing innovations continue to enhance its therapeutic potential. This review discusses the potential of phage display technology for empowering healthcare through demonstrating its development in various biological fields in recent years.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Monoclonal and Polyclonal Antibodies Research · Advanced Biosensing Techniques and Applications · Bacteriophages and microbial interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology
Huazhong University of Science and Technology
Funding
National Natural Science Foundation of China
References (100+)
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