Organoids in Dynamic Culture: Microfluidics and 3D Printing Technologies
Source abstract
Abstract
With the rapid advancement of biomaterials and tissue engineering technologies, organoid research and its applications have made significant strides. Organoids are increasingly utilized in pharmacology, regenerative medicine, and precision clinical medicine. Current trends in organoid research are moving toward multifunctional composite three-dimensional cultivation and dynamic cultivation strategies. Key technologies driving this evolution, including 3D printing and microfluidics, continue to impact new areas of discovery and clinical relevance. This review provides a systematic overview of these emerging trends, discussing the strengths and limitations of these critical technologies and offering insight and research directions for professionals working in the organoid field.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Electrohydrodynamics and Fluid Dynamics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Basic Medical Sciences
Dalian Medical University
Advanced Institute for Medical Sciences
Department of Biomedical Engineering
Tufts University
Funding
National Key Research and Development Program of China
References (100+)
Show source-provided references
1. 10.1038/s41392-022-01024-910.1038/s41392-022-01024-9 ↗
2. 10.1146/annurev-pathmechdis-012419-03261110.1146/annurev-pathmechdis-012419-032611 ↗
3. 10.1038/ncb331210.1038/ncb3312 ↗
4. 10.1007/s00109-024-02455-310.1007/s00109-024-02455-3 ↗
5. 10.1073/pnas.78.12.763410.1073/pnas.78.12.7634 ↗
6. 10.1126/science.282.5391.114510.1126/science.282.5391.1145 ↗
7. 10.1016/j.cell.2006.07.02410.1016/j.cell.2006.07.024 ↗
8. 10.1016/j.stem.2007.05.01210.1016/j.stem.2007.05.012 ↗
9. 10.1038/nrm185810.1038/nrm1858 ↗
10. 10.1016/j.bcp.2023.11558610.1016/j.bcp.2023.115586 ↗
11. 10.1039/D3LC00963G10.1039/D3LC00963G ↗
12. 10.1038/nature0793510.1038/nature07935 ↗
13. 10.1515/mr-2023-004710.1515/mr-2023-0047 ↗
14. 10.1038/s41563-021-01057-510.1038/s41563-021-01057-5 ↗
15. 10.1038/nm.443810.1038/nm.4438 ↗
16. 10.1038/s41467-022-29279-410.1038/s41467-022-29279-4 ↗
17. 10.1007/s12079-021-00643-110.1007/s12079-021-00643-1 ↗
18. 10.1016/j.semcdb.2022.10.00110.1016/j.semcdb.2022.10.001 ↗
19. 10.3390/cells1111182810.3390/cells11111828 ↗
20. 10.1016/j.bios.2023.11527110.1016/j.bios.2023.115271 ↗
21. 10.1111/cts.1306610.1111/cts.13066 ↗
22. 10.1002/adhm.20220045410.1002/adhm.202200454 ↗
23. 10.1007/978-3-030-36588-2_910.1007/978-3-030-36588-2_9 ↗
24. 10.1016/j.actbio.2024.03.03210.1016/j.actbio.2024.03.032 ↗
25. 10.1161/ATVBAHA.123.31823310.1161/ATVBAHA.123.318233 ↗
26. 10.1038/s41568-018-0104-610.1038/s41568-018-0104-6 ↗
27. 10.1038/nature1311810.1038/nature13118 ↗
28. 10.1039/D3LC00796K10.1039/D3LC00796K ↗
29. 10.1038/s41467-022-30384-710.1038/s41467-022-30384-7 ↗
30. 10.1098/rsob.21033310.1098/rsob.210333 ↗
31. 10.3389/fbioe.2024.136628010.3389/fbioe.2024.1366280 ↗
32. 10.1016/j.bios.2019.11196610.1016/j.bios.2019.111966 ↗
33. 10.1021/acsabm.3c0080610.1021/acsabm.3c00806 ↗
34. 10.1016/j.biomaterials.2022.12163910.1016/j.biomaterials.2022.121639 ↗
35. 10.1111/aor.1401710.1111/aor.14017 ↗
36. 10.1039/D1LC00535A10.1039/D1LC00535A ↗
37. 10.1002/adma.20220508210.1002/adma.202205082 ↗
38. 10.1007/s00204-021-03212-y10.1007/s00204-021-03212-y ↗
39. 10.1038/s41576-022-00466-910.1038/s41576-022-00466-9 ↗
40. 10.1007/s42242-020-00124-110.1007/s42242-020-00124-1 ↗
41. 10.1002/cphy.c18002010.1002/cphy.c180020 ↗
42. 10.3389/fphys.2016.0004110.3389/fphys.2016.00041 ↗
43. 10.1038/s41551-021-00743-810.1038/s41551-021-00743-8 ↗
44. 10.3390/cells812162010.3390/cells8121620 ↗
45. 10.3389/fbioe.2022.89869910.3389/fbioe.2022.898699 ↗
46. 10.1007/7651_2024_52710.1007/7651_2024_527 ↗
47. 10.1007/978-1-4939-7021-6_1210.1007/978-1-4939-7021-6_12 ↗
48. 10.1007/s10616-018-0194-810.1007/s10616-018-0194-8 ↗
49. 10.3389/fnut.2023.119236510.3389/fnut.2023.1192365 ↗
50. 10.1038/s41596-024-00976-210.1038/s41596-024-00976-2 ↗
51. 10.1088/1758-5090/ac992a10.1088/1758-5090/ac992a ↗
52. 10.1038/s41596-023-00814-x10.1038/s41596-023-00814-x ↗
53. 10.1002/hep.3103710.1002/hep.31037 ↗
54. 10.1038/s41578-020-0199-810.1038/s41578-020-0199-8 ↗
55. 10.1016/j.canlet.2021.01.02510.1016/j.canlet.2021.01.025 ↗
56. 10.1039/D2BM00589A10.1039/D2BM00589A ↗
57. 10.1186/s12885-023-10966-410.1186/s12885-023-10966-4 ↗
58. 10.3389/fonc.2022.82611310.3389/fonc.2022.826113 ↗
59. 10.3389/fphar.2018.0000610.3389/fphar.2018.00006 ↗
60. 10.1186/s40170-022-00285-w10.1186/s40170-022-00285-w ↗
61. 10.1038/s41598-022-09508-y10.1038/s41598-022-09508-y ↗
62. 10.3389/fbioe.2022.81194210.3389/fbioe.2022.811942 ↗
63. 10.3390/gels812082910.3390/gels8120829 ↗
64. 10.3389/fbioe.2022.92175510.3389/fbioe.2022.921755 ↗
65. 10.1016/j.jss.2016.12.02810.1016/j.jss.2016.12.028 ↗
66. 10.1016/j.stemcr.2018.06.01810.1016/j.stemcr.2018.06.018 ↗
67. 10.1016/j.xpro.2023.10258010.1016/j.xpro.2023.102580 ↗
68. 10.1039/D2AN01344D10.1039/D2AN01344D ↗
69. 10.1039/D1LC00689D10.1039/D1LC00689D ↗
70. 10.1088/1758-5090/ac2ef910.1088/1758-5090/ac2ef9 ↗
71. 10.1002/smll.20230442710.1002/smll.202304427 ↗
72. 10.1016/j.mcpro.2021.10018110.1016/j.mcpro.2021.100181 ↗
73. 10.1016/j.bioactmat.2023.06.00410.1016/j.bioactmat.2023.06.004 ↗
74. 10.3390/bios1201000610.3390/bios12010006 ↗
75. 10.1021/acssensors.0c0152410.1021/acssensors.0c01524 ↗
76. 10.1089/ten.tec.2021.019610.1089/ten.tec.2021.0196 ↗
77. 10.3390/ijms24141142710.3390/ijms241411427 ↗
78. 10.1039/D1LC00011J10.1039/D1LC00011J ↗
79. 10.1038/s41467-022-35619-110.1038/s41467-022-35619-1 ↗
80. 10.1080/17425247.2023.215200010.1080/17425247.2023.2152000 ↗
81. 10.1016/j.bios.2023.11528510.1016/j.bios.2023.115285 ↗
82. 10.1016/j.msec.2020.11106010.1016/j.msec.2020.111060 ↗
83. 10.1186/s12938-020-0752-010.1186/s12938-020-0752-0 ↗
84. 10.3389/fbioe.2020.0089510.3389/fbioe.2020.00895 ↗
85. 10.1038/s41467-024-45710-410.1038/s41467-024-45710-4 ↗
86. 10.1016/j.celrep.2021.10902610.1016/j.celrep.2021.109026 ↗
87. 10.1038/s41551-022-00882-610.1038/s41551-022-00882-6 ↗
88. 10.1016/j.actbio.2020.02.01510.1016/j.actbio.2020.02.015 ↗
89. 10.7150/thno.8726610.7150/thno.87266 ↗
90. 10.1016/j.biopha.2022.11286910.1016/j.biopha.2022.112869 ↗
91. 10.1038/nrm404110.1038/nrm4041 ↗
92. 10.3390/mi1507089710.3390/mi15070897 ↗
93. 10.1016/j.eng.2024.08.01810.1016/j.eng.2024.08.018 ↗
94. 10.1007/10_2020_12710.1007/10_2020_127 ↗
95. 10.7150/thno.9049210.7150/thno.90492 ↗
96. 10.17179/excli2020-302810.17179/excli2020-3028 ↗
97. 10.1021/acsnano.3c0111710.1021/acsnano.3c01117 ↗
98. 10.3390/bioengineering911067410.3390/bioengineering9110674 ↗
99. 10.3390/bios1307071210.3390/bios13070712 ↗
100. 10.3390/mi1308123810.3390/mi13081238 ↗