Factor XIII Cross-Linked Adhesive Chitosan Hydrogels
Source abstract
Abstract
Biomedical adhesives have been found to be an attractive alternative to suturing in several circumstances. However, to date most of the clinically approved formulations are based on synthetic and highly reactive toxic chemicals. In this work, we aimed to combine for the first time the bioactive properties of the cationic polysaccharide chitosan and its intrinsic electrostatic binding to negatively charged tissues with the biocompatible and clinically compliant enzymatic cross-linking scheme of fibrin glue. This synergistic activity led to the generation of a transglutaminase Factor XIII cross-linkable chitosan formulation with fast gelation kinetics, tunable mechanical properties, antibacterial activity, and strong adhesion to cartilage.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Polymer Surface Interaction Studies · Hemostasis and retained surgical items · Surgical Sutures and Adhesives
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Tissue Engineering + Biofabrication Laboratory, Department of Health Sciences & Technology, ETH Zürich, Otto-Stern-Weg 7, 8093 Zürich, Switzerland
Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland
Laboratory of Stem Cell Bioengineering, School of Life Sciences and School of Engineering, EPFL, Lausanne, 1015 Vaud, Switzerland
Funding
Schweizerischer Nationalfonds zur F??rderung der Wissenschaftlichen Forschung
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