journal article·2017-09-11

Administration of Soft Matter Lipid-DNA Nanoparticle As the Immunostimulant via Multiple Routes of Injection in Vivo

Jun-O Jin, Minseok Kwak, Li Xu, Haejoo Kim, Tae Hyeong Lee, Jae-Ouk Kim, Qing Liu, Andreas Herrmann, Peter C.W. Lee

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Abstract

We elucidated the proper routes for injecting lipid-DNA micelles formulated with an oligonucleotide immune adjuvant in naïve and tumor-bearing mice. We report herein that after assessing six ways of administering an immunostimulatory nanoparticle (INP), several of the injection routes effectively induced dendritic cell-mediated immune-stimulation in vivo, making them amenable to cancer immunotherapies and vaccines using such DNA materials.
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Research context

OpenAlex topics: Immunotherapy and Immune Responses · RNA Interference and Gene Delivery · Immune Cell Function and Interaction

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, 2901 Caolang Road, Shanghai 201508, China

Department of Chemistry, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, South Korea

Department of Biomedical Sciences, University of Ulsan College of Medicine, ASAN Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05535, South Korea

International Vaccine Institute, SNU Research Park, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea

Zernike Institute for Advanced Materials, Department of Polymer Chemistry, University of Groningen,, Nijenborgh 4, 9747 AG Groningen, The Netherlands

Funding

Pukyong National University

References (22)

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