DataVXACS Biomaterials Science & EngineeringPaper
journal article·2019-02-11

Incorporation of Stromal Cell-Derived Factor-1α in Three-Dimensional Hydroxyapatite/Polyacrylonitrile Composite Scaffolds for Bone Regeneration

Jieda Wang, Jiayan Li, Yeming Lu, Huifang Yang, Nanrui Hong, Lin Jin, Yan Li, Shuyi Wu

ACS Biomaterials Science & Engineering· Volume 5· Issue 2
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Source abstract

Abstract

Bone regeneration strategies rely on biomaterial constructs with stem cells or growth factors. By comparison, cell homing strategies employ chemokines to recruit the host endogenous stem or progenitor cells to the defect site to support endogenous healing. In the present study, we used a novel fluffy hydroxyapatite/polyacrylonitrile (HA/PAN) composite scaffold to provide a better three-dimensional cell culture microenvironment. These HA/PAN composite scaffolds loaded with stromal cell-derived factor-1α (SDF-1α) provided a diffusion-controlled SDF-1α release profile and endowed the scaffolds with cell homing capabilities. Furthermore, the scaffolds significantly stimulated bone marrow stromal cell (BMSC) recruitment, facilitated BMSC osteogenic differentiation, and promoted ectopic bone formation. Our results suggest that a HA/PAN composite scaffold loaded with SDF-1α offers a clinically beneficial bone repair strategy.
Source: openalex_inverted_index · Quality: baseline

Research context

BiomaterialsComposites

OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Mesenchymal stem cell research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, No. 56, Lingyuan West Road, Guangzhou 510055, China

Department of Stomatology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Guangzhou 510000, China

Department of Stomatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 16, Airport Road, Guangzhou 510405, China

International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, No. 6, Wenchang Road, Zhoukou 466001, China

Funding

China Postdoctoral Science Foundation · Henan University · Guangdong Province · Key Laboratory of Polymeric Composite and Functional Materials, Ministry of Education of the People's Republic of China

References (45)

Show source-provided references
1. Rai R. · J. Int. Oral Health · 2015 · 7 · 138
2. 10.1007/s00441-018-2837-710.1007/s00441-018-2837-7 ↗
3. 10.1002/term.266810.1002/term.2668 ↗
4. 10.1016/j.biomaterials.2013.09.04010.1016/j.biomaterials.2013.09.040 ↗
5. 10.1002/jbm.b.3400310.1002/jbm.b.34003 ↗
6. 10.1166/jnn.2014.919510.1166/jnn.2014.9195 ↗
7. 10.1039/C3TB21219J10.1039/C3TB21219J ↗
8. 10.1038/boneres.2015.2910.1038/boneres.2015.29 ↗
9. 10.1016/S0142-9612(03)00037-110.1016/S0142-9612(03)00037-1 ↗
10. 10.1016/j.actbio.2012.01.03110.1016/j.actbio.2012.01.031 ↗
11. 10.1007/s00170-013-5001-210.1007/s00170-013-5001-2 ↗
12. 10.1039/C7RA12449J10.1039/C7RA12449J ↗
13. 10.1016/S0142-9612(03)00044-910.1016/S0142-9612(03)00044-9 ↗
14. 10.1089/ten.teb.2009.065810.1089/ten.teb.2009.0658 ↗
15. 10.1016/S0140-6736(10)60668-X10.1016/S0140-6736(10)60668-X ↗
16. 10.1016/j.biomaterials.2016.08.02310.1016/j.biomaterials.2016.08.023 ↗
17. 10.1016/j.biomaterials.2014.03.07010.1016/j.biomaterials.2014.03.070 ↗
18. 10.1016/j.biomaterials.2014.10.04910.1016/j.biomaterials.2014.10.049 ↗
19. 10.1016/j.actbio.2017.07.03210.1016/j.actbio.2017.07.032 ↗
20. 10.1038/emm.2013.11810.1038/emm.2013.118 ↗
21. 10.1089/ten.teb.2013.010010.1089/ten.teb.2013.0100 ↗
22. 10.1161/01.CIR.0000055313.77510.2210.1161/01.CIR.0000055313.77510.22 ↗
23. 10.1182/blood-2004-02-052610.1182/blood-2004-02-0526 ↗
24. 10.1016/j.scr.2011.05.00310.1016/j.scr.2011.05.003 ↗
25. 10.1002/art.2433010.1002/art.24330 ↗
26. 10.3389/fbioe.2015.0007910.3389/fbioe.2015.00079 ↗
27. 10.1096/fj.12-21021110.1096/fj.12-210211 ↗
28. 10.1016/j.biomaterials.2010.01.14410.1016/j.biomaterials.2010.01.144 ↗
29. 10.1002/mabi.20150017810.1002/mabi.201500178 ↗
30. 10.1016/j.biomaterials.2012.10.01610.1016/j.biomaterials.2012.10.016 ↗
31. 10.1021/acsanm.7b0018810.1021/acsanm.7b00188 ↗
32. Kim C. H. · Blood · 1998 · 91 · 10010.1182/blood.V91.1.100 ↗
33. 10.1016/j.apmt.2018.06.00810.1016/j.apmt.2018.06.008 ↗
34. 10.1016/S0168-3659(01)00248-610.1016/S0168-3659(01)00248-6 ↗
35. 10.1163/156856209X41019310.1163/156856209X410193 ↗
36. 10.1634/stemcells.2007-051510.1634/stemcells.2007-0515 ↗
37. 10.1016/j.jconrel.2014.11.00310.1016/j.jconrel.2014.11.003 ↗
38. 10.22203/eCM.v028a1910.22203/eCM.v028a19 ↗
39. 10.1016/j.biomaterials.2010.12.05210.1016/j.biomaterials.2010.12.052 ↗
40. 10.1016/j.biocel.2010.03.02010.1016/j.biocel.2010.03.020 ↗
41. 10.1126/science.286.5446.194610.1126/science.286.5446.1946 ↗
42. 10.1016/S0092-8674(01)00622-510.1016/S0092-8674(01)00622-5 ↗
43. 10.1002/jcp.2098810.1002/jcp.20988 ↗
44. 10.1002/mabi.20090010710.1002/mabi.200900107 ↗
45. 10.1080/104281902100003798510.1080/1042819021000037985 ↗