PLA–PEG Micelles Loaded with a Classic Vasodilator for Oxidative Cataract Prevention
Source abstract
Abstract
The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA-PEG to form NFP-loaded PLA-PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage. The NFP-loaded PLA-PEG micelles not only showed satisfactory biocompatibility and bioavailability, but also efficiently improved the anticataract ability through the inhibition of extracellular calcium ions influx. This study may provide a new insight into the development of cataract treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Intraocular Surgery and Lenses · Corneal surgery and disorders · Connexins and lens biology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People’s Republic of China
Funding
National Natural Science Foundation of China
References (24)
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