Supramolecular Threading of Peptide Hydrogel Fibrils
Source abstract
Abstract
There is an increasing demand for biocompatible materials in biomedical applications. Herein, we report a modified α-helical decapeptide segment from the cardiac troponin C, which self-assembles into fibers with a secondary β-sheet structure. These fibers cross-link via a novel supramolecular threading mechanism which results in an atypical stiff hydrogel (G′ ≈ 13 kPa). In this work, we provide a first insight into the understanding of such remarkable cross-linking mechanism, which will aid in the development of new biomaterials with unique properties.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Chemical Synthesis and Analysis · Proteoglycans and glycosaminoglycans research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand
National Centre for Protein Science Shanghai, Chinese Academy of Sciences, Shanghai 201204, China
School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AF, United Kingdom
Funding
Horizon 2020 Framework Programme
References (22)
Show source-provided references
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