Ascidian-Inspired Heparin-Mimetic Magnetic Nanoparticles with Potential for Application in Hemodialysis as Recycling Anticoagulants
Source abstract
Abstract
In the present study, heparin-mimetic magnetic nanoparticles (HMNPs), which might be used as recycling anticoagulants, were synthesized by coating heparin-mimetic sodium alginate (HLSA) on the surface of iron oxide magnetic nanoparticles (MNPs), using 3,4,5-trihydroxyphenylalanine (TOPA) as a biological adhesive. HLSA was successfully immobilized on the MNP surface, as revealed by Fourier transform infrared spectroscopy and thermal gravimetric analysis, and the core (MNP)–shell (TOPA, HLSA) structure was confirmed by transmission electron microscopy observations. In addition, in vitro studies of protein adsorption, blood clotting time, and contact activation confirmed that the blood compatibility of the HMNP was significantly enhanced compared with the bare MNP. The improved hemocompatibility was attributed to the introduction of the multiple heparin-mimetic groups (−SO3Na, −COONa, and −OH). In addition, the HMNP showed outstanding recycle stability and, thus, can be reused if needed. The synthesized HMNP appeared to be a suitable biomaterial to safely replace heparin as an anticoagulant in patients undergoing long-term hemodialysis.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Hemostasis and retained surgical items · Intracranial Aneurysms: Treatment and Complications · Blood properties and coagulation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Materials Engineering, Huaiyin Institute of Technology, Huaian 223003, China
Department of Chemistry and Biochemistry, Georgia Southern University, P.O. Box 8064, Statesboro, Georgia 30460, United States
Funding
Natural Science Foundation of Jiangsu Province · Georgia Southern University · National Natural Science Foundation of China
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