Biocompatible Star Block Copolymer Hydrogel Cross-linked with Calcium Ions
Source abstract
Abstract
Hydrogels cross-linked with calcium ions (Ca 2+ ) have various potential medical applications. A star block copolymer with a dendritic polyester (DPE) core and double hydrophilic block copolymer arms composed of oligo(ethylene glycol) methyl ether acrylate (OEGA) and acrylic acid (AA) has been synthesized for the first time. This star block copolymer showed a spherical morphology with an average diameter of 62 nm and rapidly formed a hydrogel in normal saline under physiological conditions when it was mixed with Ca 2+ . Furthermore, the star block copolymer and its hydrogel cross-linked by Ca 2+ showed excellent biocompatibility both in vitro and in vivo.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Polymer Synthesis and Characterization · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Funding
Japan Society for the Promotion of Science
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