journal article·2017-10-09

Oxygen-Releasing Coatings for Improved Tissue Preservation

Aurelien Forget, Camille Staehly, Neethu Ninan, Frances J. Harding, Krasimir Vasilev, Nicolas H. Voelcker, Anton Blencowe

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Abstract

Current organ transplantation protocols require the rapid transport of freshly isolated donor tissue to the recipient patient at the site where the procedure is to be conducted. During transport, the tissue graft can quickly deteriorate as a result of oxygen starvation. In this study, we report the fabrication of oxygen-releasing coatings for improved tissue preservation. The coatings were prepared via the encapsulation of calcium peroxide or urea peroxide microparticles between layers of octadiene plasma polymer films. By varying the thickness of the plasma polymer coating and type of peroxide, formulations were obtained that generate oxygen upon contact with aqueous solutions, while at the same time limiting the amount of toxic reactive oxygen species produced. The optimized coatings were tested under hypoxic conditions using the MIN6 β-cell line, which resulted in a 3-fold increase in the viability of cultured cells. These thin oxygen-releasing coatings can be deposited on a wide range of surfaces, creating a platform for oxygen delivery with the potential to extend the viability of transported tissues and increase the time frame available for graft transport.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Pancreatic function and diabetes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5000, Australia

Collaborative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Adelaide, South Australia 5000, Australia

School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland 4001, Australia

Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia

Cell Therapies Pty Ltd, Victorian Comprehensive Cancer Centre (VCCC), Melbourne, Victoria 3000, Australia

School of Engineering, University of South Australia, Mawson Lakes, South Australia 5095, Australia

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton, Victoria 3168, Australia

Funding

Cooperative Research Centres, Australian Government Department of Industry

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