journal article·2018-07-09Open access

Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions

Dongfei Liu, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei Mäkilä, Jarno Salonen, Risto Kostiainen, Jouni Hirvonen, Tapio Kotiaho, Hélder A. Santos

Abstract

-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Silicon Nanostructures and Photoluminescence · Advanced biosensing and bioanalysis techniques · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China

Department of Pharmaceutical Science, Åbo Akademi University, Turku FI-20520, Finland

Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, Turku FI-20014, Finland

Funding

Tekes · Jane ja Aatos Erkon S??ti? · Suomen Akatemia · Helsingin Yliopiston Tiedes??ti? · FP7 Ideas: European Research Council · Helsinki Institute of Life Science, Helsingin Yliopisto

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