DataVXACS Biomaterials Science & EngineeringPaper
journal article·2017-01-09

Membrane Fusion-Mediated Gold Nanoplating of Red Blood Cell: A Bioengineered CT-Contrast Agent

Santosh Aryal, Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Tej B. Shrestha, David Biller, Deryl Troyer

ACS Biomaterials Science & Engineering· Volume 3· Issue 1
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Source abstract

Abstract

Red blood cells (RBCs) are the natural resident of the vascular lumen, therefore delivery of any agents within the vascular lumen could benefit by unique natural transporting features of RBCs. RBCs continuously circulate for ∼100 days before being sequestered in the spleen, they only extravasate at sites of vascular hemorrhage. Taking advantages of these features, we engineered RBC as a carrier in order to design a unique delivery system capable of delivering X-ray computed tomography (CT) contrast agents, gold nanoparticles (AuNPs), thereby acting as CT-contrast agent. A strategic membrane fusion technique was used to engineer the surface of RBC with gold nanoparticles in this in vitro study without altering its shape, size, and surface properties.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Erythrocyte Function and Pathophysiology · Blood properties and coagulation · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Kansas State University, 1212 Mid-Campus Drive North, Manhattan, Kansas 66506, United States

Nanotechnology Innovation Center of Kansas State (NICKS), Kansas State University, 1800 Denison Avenue, Manhattan, Kansas 66506, United States

Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, 228 Coles Hall, Manhattan, Kansas 66506, United States

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, A-111 Mosier Hall, Manhattan, Kansas 66506, United States

Funding

Kansas State University · Nanotechnology Innovation Center of Kansas State · Johnson Cancer Research Center

References (35)

Show source-provided references
1. 10.1517/14656566.7.8.104110.1517/14656566.7.8.1041 ↗
2. 10.1039/c2cs15344k10.1039/c2cs15344k ↗
3. 10.1371/journal.pone.015207410.1371/journal.pone.0152074 ↗
4. 10.1038/nrd259110.1038/nrd2591 ↗
5. 10.1039/C6RA02026G10.1039/C6RA02026G ↗
6. 10.1517/1742524100361063310.1517/17425241003610633 ↗
7. 10.1016/S0304-4165(02)00536-610.1016/S0304-4165(02)00536-6 ↗
8. 10.1007/BF0185219310.1007/BF01852193 ↗
9. 10.1126/science.82114510.1126/science.821145 ↗
10. 10.1007/BF0192192410.1007/BF01921924 ↗
11. 10.1016/j.jconrel.2014.03.03810.1016/j.jconrel.2014.03.038 ↗
12. 10.1124/jpet.109.15919410.1124/jpet.109.159194 ↗
13. 10.1002/mrm.191040011810.1002/mrm.1910400118 ↗
14. 10.1007/978-1-4615-3030-5_4210.1007/978-1-4615-3030-5_42 ↗
15. 10.1126/science.108932410.1126/science.1089324 ↗
16. 10.1182/blood-2013-06-50895210.1182/blood-2013-06-508952 ↗
17. Bove J. R. · Immunology · 1973 · 25 · 793
18. 10.1016/0005-2736(92)90336-K10.1016/0005-2736(92)90336-K ↗
19. 10.2147/DDDT.S9647010.2147/DDDT.S96470 ↗
20. 10.7150/thno.1185210.7150/thno.11852 ↗
21. 10.1021/mp300254s10.1021/mp300254s ↗
22. 10.1073/pnas.080664710610.1073/pnas.0806647106 ↗
23. 10.1021/nl072209h10.1021/nl072209h ↗
24. 10.1016/j.nano.2012.10.00610.1016/j.nano.2012.10.006 ↗
25. 10.2217/nnm.14.1310.2217/nnm.14.13 ↗
26. 10.1016/j.biomaterials.2016.05.00210.1016/j.biomaterials.2016.05.002 ↗
27. 10.1021/nn901858710.1021/nn9018587 ↗
28. 10.1006/meth.2001.121710.1006/meth.2001.1217 ↗
29. 10.1039/c2cc18176b10.1039/c2cc18176b ↗
30. Cooper G. M. · 2000
31. 10.1117/1.200336910.1117/1.2003369 ↗
32. 10.1016/j.compmedimag.2013.12.00810.1016/j.compmedimag.2013.12.008 ↗
33. 10.1117/1.JBO.19.4.04601010.1117/1.JBO.19.4.046010 ↗
34. 10.1016/j.jhazmat.2014.08.04910.1016/j.jhazmat.2014.08.049 ↗
35. 10.1002/jbio.20130006710.1002/jbio.201300067 ↗