DataVXACS Biomaterials Science & EngineeringPaper
journal article·2025-07-14

Multifunctional Bioactive Cu–Sm-Based Nanozyme Systems for Psoriasis Therapy

Hui Yuan, Jiangshan Hu, Hao Sun, Peiyuan Wang, Can-zhong Lu, Xiaofeng Wu, Xiaohua Xie, Jiayu Chen, Jie Han, Ting Hu, Jinsheng Liao, Yuhang Li

ACS Biomaterials Science & Engineering· Volume 11· Issue 7
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Source abstract

Abstract

As a persistent inflammatory dermatological disorder, psoriasis impacts a global population of millions, with existing therapies frequently limited by side effects, high toxicity, and low effectiveness. Herein, we present the design and synthesis of a copper–samarium (Cu–Sm)-based bimetallic nanozyme (CS NPs) with strong antioxidant and anti-inflammatory characteristics for psoriasis therapy. CS NPs imitate natural antioxidant enzymes and efficiently neutralize H 2 O 2, • OH, and O 2 •– . Characterization investigations have confirmed the nanoparticles’ stability, appropriate Sm doping ratio, and catalytic effectiveness. In vitro, CS NPs decrease ROS levels, restrict keratinocyte proliferation, and regulate inflammatory cytokine release through NF-κB pathway inhibition in HaCaT cells activated with IL-17. In vivo, CS NPs ameliorate IMQ-triggered psoriasiform lesions in mouse models through suppression of epidermal acanthosis, immune cell infiltration, and inflammatory marker expression. These results demonstrate the therapeutic potential of Cu–Sm nanozymes to provide biocompatible and effective psoriasis treatment, offering a viable substitute for conventional therapies.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemistry and Chemical Engineering/Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry

Jiangxi University of Science and Technology

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter

Chinese Academy of Sciences

Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials

Xiamen Institute of Rare Earth Materials, Haixi Institutes, Chinese Academy of Sciences

Fujian College

University of Chinese Academy of Sciences

Department of Pharmacy

The First Affiliated Hospital of Xiamen University

Department of Pediatrics, Pediatric Key Laboratory of Xiamen, the First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Xiamen 361003, P. R. China

Institute of Pediatrics, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen 361003, P. R. China

School of Science and Technology

Hong Kong Metropolitan University

Funding

Natural Science Foundation of Fujian Province · Natural Science Foundation of Xiamen Municipality · National Natural Science Foundation of China · Natural Science Foundation of Jiangxi Province · High-quality Development Project of Public Hospitals in Xiamen City · Xiamen Medical and Health Guidance Project · Science and Technology Service Network Initiative from Chinese Academy of Science

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