Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility
Source abstract
Abstract
High Resolution Image Download MS PowerPoint Slide This study explores the synergistic effects of combining titania nanotubes (TiNTs) with the biopolymer Tanfloc (TAN) to enhance the surface properties of TiNTs for biomedical applications. We investigated the interactions of blood components and human adipose-derived stem cells (ADSCs) with TiNT surfaces covalently functionalized with Tanfloc (TAN), an aminolyzed polyphenolic tannin derivative. The functionalized surfaces (TiNT-TAN) have great potential to control protein adsorption and platelet adhesion and activation. Fluorescence and scanning electron microscopy (SEM) were used to analyze platelet adherence and activation. The amphoteric nature and multiple functional groups on TAN can control blood protein adsorption, platelet adhesion, and activation. Further, the modified surface supports adipose-derived stem cell (ADSC) viability, attachment, and growth without any cytotoxic effect. The TAN conjugation significantly (**** p < 0.0001) increased the proliferation rate of ADSCs compared to the TiNT surfaces.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Polymer Surface Interaction Studies · Hemostasis and retained surgical items
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering, College of Engineering and Computing
George Mason University
Department of Mechanical Engineering
Colorado State University
Department of Chemical and Biological Engineering
Department of Chemistry
Pittsburgh State University
Funding
National Institute of Biomedical Imaging and Bioengineering · George Mason University · Division of Materials Research
References (72)
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