DataVXACS Biomaterials Science & EngineeringPaper
journal article·2024-12-09

Outer Membrane Vesicle–Cancer Hybrid Membrane Coating Indocyanine Green Nanoparticles for Enhancing Photothermal Therapy Efficacy in Tumors

Jing Zhao, Bo Yu, Lujing Li, Sihua Guo, Xuan Sha, Waner Ru, Guo-Qing Du, Jing-Yi Xue

ACS Biomaterials Science & Engineering· Volume 10· Issue 12
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Source abstract

Abstract

Cell membrane-coated nanomaterials are increasingly recognized as effective in cancer treatment due to their unique benefits. This study introduces a novel hybrid membrane coating nanoparticle, termed cancer cell membrane (CCM)-outer membrane vesicle (OMV)@Lip-indocyanine green (ICG), which combines CCMs with bacterial OMV to encapsulate ICG-loaded liposomes. Comprehensive analyses were conducted to assess its physical and chemical properties as well as its functionality. Demonstrating targeted delivery capabilities and good biocompatibility, CCM-OMV@Lip-ICG nanoparticles showed promising photothermal and immunotherapeutic effects in tumor models. By inducing hyperthermia-induced tumor therapy and bolstering antitumor immunity, CCM-OMV@Lip-ICG nanoparticles exhibit a synergistic therapeutic effect, providing a new perspective for the management of cancer.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Cardiovascular Institution, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China

Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Ultrasound Molecular Imaging Joint Laboratory of Heilongjiang Province, Harbin 150028, China

Department of Ultrasound, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China

College of Medicine, Shantou University, Shantou 515041, China

Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

Department of Cardiology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Science), Southern Medical University, Guangzhou 510080, China

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