DataVXACS Biomaterials Science & EngineeringPaper
journal article·2023-11-13

PD-L1-Expressing Extracellular Vesicles for the Treatment of Pneumonia

Yi Wu, Heng Wang, Anning Song, Xiaoyu Wang, Qingle Ma, Chenlu Yao, Jialu Xu, Huaxing Dai, Chao Wang, Ting Lu, Fang Xu

ACS Biomaterials Science & Engineering· Volume 9· Issue 11
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Source abstract

Abstract

Acute respiratory distress syndrome (ARDS) is a severe lung condition with a high mortality rate and a lack of effective drug therapy. In this work, we developed mesenchymal stem cell (MSC)-derived extracellular vesicles with high PD-L1 expression (MSC-EVs-PD-L1) for treating lipopolysaccharide (LPS)-induced pneumonia by intratracheal administration. We found an upregulation of PD-1 expression in the inflammatory region of murine lungs; hence, MSC-EVs-PD-L1 exerted immunosuppressive effects via the PD-1/PD-L1 signaling pathway. Furthermore, we treated LPS-induced pneumonia mice by intratracheal administration, which enabled heavy drug accumulation in the lungs of mice and better therapeutic efficacy compared to systemic administration. Our results suggest that MSC-EVs-PD-L1 has the potential to provide a universal platform technology for the immunotherapy of pneumonia.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Extracellular vesicles in disease · Immune cells in cancer · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China

Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu 215123, China

Funding

Natural Science Research of Jiangsu Higher Education Institutions of China · Collaborative Innovation Center of Suzhou Nano Science and Technology · National Key Research and Development Program of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Higher Education Discipline Innovation Project

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