DataVXACS Biomaterials Science & EngineeringPaper
journal article·2024-09-09Open access

Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage

Elizabeth R. Kahle, Hooman Fallahi, Annika R. Bergstrom, Anita Li, Colette E. Trouillot, Mary K. Mulcahey, X. Lucas Lu, Lin Han, Michele S. Marcolongo

ACS Biomaterials Science & Engineering· Volume 10· Issue 9
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Source abstract

Abstract

In osteoarthritis (OA), degradation of cartilage pericellular matrix (PCM), the proteoglycan-rich immediate cell microniche, is a leading event of disease initiation. This study demonstrated that biomimetic proteoglycans (BPGs) can diffuse into human cartilage from both normal and osteoarthritic donors and are preferentially localized within the PCM. Applying immunofluorescence (IF)-guided AFM nanomechanical mapping, we show that this localization of BPGs increases the PCM micromodulus of both normal and OA specimens. These results illustrate the capability of BPGs to integrate with degenerative tissues and support the translational potential of BPGs for treating human OA and other diseases associated with proteoglycan degradation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Proteoglycans and glycosaminoglycans research · Cell Adhesion Molecules Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States

Department of Chemical and Biological Engineering, Villanova University, Villanova, Pennsylvania 19085, United States

Department of Mechanical Engineering, Villanova University, Villanova, Pennsylvania 19085, United States

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois 60153, United States

Department of Mechanical Engineering, University of Delaware, Newark, Delaware 19716, United States

Funding

Division of Civil, Mechanical and Manufacturing Innovation · National Institute of Arthritis and Musculoskeletal and Skin Diseases

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