DataVXACS Biomaterials Science & EngineeringPaper
journal article·2025-01-13

Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

Hao Li, Dayan Li, Xue Wang, Ziyuan Zeng, Sara Pahlavan, Wei Zhang, Xi Wang, Kai Wang

ACS Biomaterials Science & Engineering· Volume 11· Issue 1
Publisher page
Source abstract

Abstract

Sufficient vascular system and adequate blood perfusion is crucial for ensuring nutrient and oxygen supply within biomaterials. Actively exploring the optimal physical properties of biomaterials in various application scenarios has provided clues for enhancing vascularization within materials, leading to improved outcomes in tissue engineering and clinical translation. Here we focus on reviewing the physical properties of biomaterials, including pore structure, surface topography, and stiffness, and their effects on promoting vascularization. This angiogenic capability has the potential to provide better standardized research models and personalized treatment strategies for bone regeneration, wound healing, islet transplantation and cardiac repair.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Clinical Stem Cell Research Center, Peking University Third Hospital, Peking University, Beijing 100191, China

State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 16635-148, Iran

TianXinFu (Beijing) Medical Appliance Co., Ltd., Beijing 102200, China

Funding

National Key Research and Development Program of China · Peking University Third Hospital · Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park · Natural Science Foundation of Beijing Municipality · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Beijing Nova Program · Elite Support Program · State Key Laboratory of Female Fertility Promotion · Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease · Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital · State Key Laboratory of Cardiovascular Disease, Fuwai Hospital · Emerging Engineering Interdisciplinary-Young Scholars Project, Peking University · State Key Laboratory of Digital Medical Engineering, Southeast University · Clinical Medicine Plus X-Young Scholars Project, Peking University · Scientific and Technological Innovation project of China Academy of Chinese Medical Science

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