DataVXACS Biomaterials Science & EngineeringPaper
journal article·2023-02-13

Poly β-Cyclodextrin/Quaternary Ammoniated Chitosan Cryogel with a Porous Structure for Effective Hemostasis

Min Tan, Fan Liu, Li-Guo Liao, Jun-Feng Feng, Fu-Zhong Zhang, Shu-Ting Fan, Jia-Xin Wang, Kun Guo, Bang-Jing Li, Sheng Zhang

ACS Biomaterials Science & Engineering· Volume 9· Issue 2
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Source abstract

Abstract

Uncontrolled bleeding is one of the most important causes threatening human health, but quick hemostasis remains a challenge. We prepared porous cryogels with poly β-cyclodextrin (Pβ-CD) and quaternary ammoniated chitosan (QCs). Pβ-CD acts as a "water-grabbing agent" to assist QCs' ability to absorb and concentrate blood rapidly. The rat-tail amputation model and liver injury model exhibited that cryogels had excellent hemostatic performance. Moreover, cryogels showed good antibacterial activity and biocompatibility. Therefore, these cryogels can be used as potential hemostatic materials.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Hemostasis and retained surgical items · Trauma, Hemostasis, Coagulopathy, Resuscitation · Hemophilia Treatment and Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu610041, China

University of Chinese Academy of Sciences, Beijing100049, China

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Sichuan University, Chengdu610065, China

College of Pharmacy, Southwest Minzu University, Chengdu610041, China

Funding

National Natural Science Foundation of China · Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province

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