Cerium Coatings on Pristine and Nanostructured Ti and Ti6Al4V Surfaces: Bioactivity, Resistance in Simulated Inflammatory Conditions, and Antibacterial Performance

Serena De Santis; Romualdo Varricchio; Anita Ceccucci; Giovanni Sotgiu; Alessandra Di Masi; Gabriele Magna; Simona Sennato; Monica Orsini

doi:10.1021/acsbiomaterials.2c01461

journal article·2023-06-12

Cerium Coatings on Pristine and Nanostructured Ti and Ti6Al4V Surfaces: Bioactivity, Resistance in Simulated Inflammatory Conditions, and Antibacterial Performance

Serena De Santis, Romualdo Varricchio, Anita Ceccucci, Giovanni Sotgiu, Alessandra Di Masi, Gabriele Magna, Simona Sennato, Monica Orsini

ACS Biomaterials Science & Engineering· Volume 9· Issue 6

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Source abstract

Abstract

Despite the significant contribution of titanium and its alloys for hard tissue regenerative medicine, some major issues remain to be solved. Implants’ long-term stability is threatened by poor osseointegration. Moreover, bacterial adhesion and excessive inflammatory response are also to be considered in the design of a device intended to be integrated into the human body. Here, a cerium mixed oxide (CeO x ) coating was realized on pristine and nanotubular-structured Ti and Ti6Al4V surfaces using a simple layer-by-layer drop-casting technique. Bioactivity, resistance in simulated inflammatory conditions, and bactericidal capacity were evaluated as a function of morphological surface characteristics combined with the cerium quantity deposited. The results obtained suggest that the presence of CeO x on the surfaces with nanotubes enhanced osseointegration, while on the non-nanostructured surfaces, this coating improved resistance under oxidative stress and provided excellent antibacterial properties.

Source: openalex_inverted_index · Quality: baseline

Research context

Metals & alloys Nanomaterials Biomaterials

OpenAlex topics: Bone Tissue Engineering Materials · MXene and MAX Phase Materials · Titanium Alloys Microstructure and Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Industrial, Electronic and Mechanical Engineering, Roma Tre University, Via Vito Volterra 62, 00146 Rome, Italy

Department of Science, Section of Biomedical Sciences and Technologies, Roma Tre University, Viale Guglielmo Marconi 446, 00146 Rome, Italy

Department of Chemical Science and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy

CNR-ISC Sede Sapienza and Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy

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