Bioinspired Conjugated Tri-Porphyrin-Based Intracellular pH-Sensitive Metallo-Supramolecular Nanoparticles for Near-Infrared Photoacoustic Imaging-Guided Chemo- and Photothermal Combined Therapy
Source abstract
Abstract
Porphyrins have been extensively used in clinical phototherapy. However, most of them exhibited absorption below 700 nm. We report conjugated tri-porphyrins showing absorption within a biological phototherapy window (700-850 nm). On this basis, bioinspired intracellular pH-sensitive metallo-supramolecular nanoparticles (NPs) are designed. They provide the simultaneous photothermal therapy and chemotherapy. After treatment by tail vein injection, the tumor was completely relieved without recurrence in a course of 27 days. These bioinspired intracellular pH-sensitive metallo-supramolecular NPs show excellent potential application in near-infrared photoacoustic imaging-guided chemo-photothermal combined therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Porphyrin and Phthalocyanine Chemistry · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Deep-Processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, No. 10, Jichang Road, Panzhihua 617000, Sichuan, P. R. China
Institute of Biomass Functional Materials Interdisciplinary Studies Jilin Engineering Normal University, No.3050, Kaixuan Road, Changchun 130052, P.R. China
Funding
Department of Science and Technology of Sichuan Province · National Natural Science Foundation of China · Science and Technology Bureau of Panzhihua
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