DataVXACS Biomaterials Science & EngineeringPaper
journal article·2024-03-11

3D Bioprinted Xanthan Hydrogels with Dual Antioxidant and Chondrogenic Functions for Post-traumatic Cartilage Regeneration

Yuting Chen, Yiguan Le, Junxu Yang, Yifeng Yang, Xianjing Feng, Jinhong Cai, Yifeng Shang, Sigit Sugiarto, Qingjun Wei, Dan Kai, Li Zheng, Jinmin Zhao

ACS Biomaterials Science & Engineering· Volume 10· Issue 3
Publisher page
Source abstract

Abstract

Intra-articular trauma typically initiates the overgeneration of reactive oxidative species (ROS), leading to post-traumatic osteoarthritis and cartilage degeneration. Xanthan gum (XG), a branched polysaccharide, has shown its potential in many biomedical fields, but some of its inherent properties, including undesirable viscosity and poor mechanical stability, limit its application in 3D printed scaffolds for cartilage regeneration. In this project, we developed 3D bioprinted XG hydrogels by modifying XG with methacrylic (MA) groups for post-traumatic cartilage therapy. Our results demonstrated that the chemical modification optimized the viscoelasticity of the bioink, improved printability, and enhanced the mechanical properties of the resulting scaffolds. The XG hydrogels also exhibit decent ROS scavenging capacities to protect stem cells from oxidative stress. Furthermore, XGMA (H) (5% MA substitution) exhibited superior chondrogenic potential in vitro and promoted cartilage regeneration in vivo . These dual-functional XGMA hydrogels may provide a new opportunity for cartilage tissue engineering.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterialsMaterials processing

OpenAlex topics: 3D Printing in Biomedical Research · Osteoarthritis Treatment and Mechanisms · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330008, China

Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Institute of Sustainability for Chemicals, Energy, and Environment (ISCE2), Agency for Science, Technology, and Research (A*STAR), 2 Fusionopolis Way, Innovis, #08-03, 138634 Republic of Singapore

Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, 138634 Republic of Singapore

Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Funding

Science and Technology Major Project of Guangxi · National Natural Science Foundation of China · RIE2025 MTC Individual Research Grants · Guangxi Scientific Research and Technological Development Foundation

References (41)

Show source-provided references
1. 10.1021/acsnano.1c0400510.1021/acsnano.1c04005 ↗
2. 10.1002/advs.20210572710.1002/advs.202105727 ↗
3. 10.1080/01652176.2019.164305110.1080/01652176.2019.1643051 ↗
4. 10.1038/s41536-021-00122-610.1038/s41536-021-00122-6 ↗
5. 10.1016/j.bioactmat.2021.01.03110.1016/j.bioactmat.2021.01.031 ↗
6. 10.1016/j.actbio.2020.05.04010.1016/j.actbio.2020.05.040 ↗
7. 10.1021/bm301382d10.1021/bm301382d ↗
8. 10.1016/j.bioactmat.2020.09.01010.1016/j.bioactmat.2020.09.010 ↗
9. 10.1016/j.carbpol.2015.06.00410.1016/j.carbpol.2015.06.004 ↗
10. 10.1021/acs.biomac.1c0080310.1021/acs.biomac.1c00803 ↗
11. 10.1016/j.foodchem.2016.07.18310.1016/j.foodchem.2016.07.183 ↗
12. 10.1016/j.carbpol.2012.11.05110.1016/j.carbpol.2012.11.051 ↗
13. 10.1016/j.bbrc.2017.10.03910.1016/j.bbrc.2017.10.039 ↗
14. 10.1016/j.carbpol.2017.01.10110.1016/j.carbpol.2017.01.101 ↗
15. 10.1016/j.ijbiomac.2019.12.13210.1016/j.ijbiomac.2019.12.132 ↗
16. 10.1016/j.carbpol.2017.10.00910.1016/j.carbpol.2017.10.009 ↗
17. 10.1016/j.ijbiomac.2023.12856210.1016/j.ijbiomac.2023.128562 ↗
18. 10.1039/D0CC00326C10.1039/D0CC00326C ↗
19. 10.1016/j.carbpol.2018.09.04410.1016/j.carbpol.2018.09.044 ↗
20. 10.1039/C8SM02605J10.1039/C8SM02605J ↗
21. 10.3390/ma1105070010.3390/ma11050700 ↗
22. 10.1016/j.joca.2007.05.00510.1016/j.joca.2007.05.005 ↗
23. 10.1177/036354650935906810.1177/0363546509359068 ↗
24. 10.1088/1758-5090/8/3/03502010.1088/1758-5090/8/3/035020 ↗
25. 10.1021/acsami.7b1973010.1021/acsami.7b19730 ↗
26. 10.1038/s41467-021-26791-x10.1038/s41467-021-26791-x ↗
27. 10.1016/j.actbio.2018.11.03910.1016/j.actbio.2018.11.039 ↗
28. 10.1016/j.carbpol.2020.11620710.1016/j.carbpol.2020.116207 ↗
29. 10.1002/advs.20200101410.1002/advs.202001014 ↗
30. 10.1088/1758-5090/aba2f710.1088/1758-5090/aba2f7 ↗
31. 10.3389/fbioe.2020.0037310.3389/fbioe.2020.00373 ↗
32. 10.1002/adhm.20230207810.1002/adhm.202302078 ↗
33. 10.1126/science.aav905110.1126/science.aav9051 ↗
34. 10.1021/acsami.7b0275610.1021/acsami.7b02756 ↗
35. 10.1016/j.msec.2017.09.00210.1016/j.msec.2017.09.002 ↗
36. 10.1016/j.biomaterials.2009.11.07010.1016/j.biomaterials.2009.11.070 ↗
37. 10.1016/j.carbpol.2020.11674310.1016/j.carbpol.2020.116743 ↗
38. 10.1016/j.jtv.2021.04.00810.1016/j.jtv.2021.04.008 ↗
39. Goodenowe D.B. · Frontiers in Cell and Developmental Biology · 2022 · 10
40. 10.1016/j.carbpol.2012.10.06910.1016/j.carbpol.2012.10.069 ↗
41. 10.1016/j.carbpol.2018.10.07310.1016/j.carbpol.2018.10.073 ↗