DataVXACS Biomaterials Science & EngineeringPaper
journal article·2024-05-13Open access

Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z. Wadghiri, Jin Kim Montclare

ACS Biomaterials Science & Engineering· Volume 10· Issue 5
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Source abstract

Abstract

Triple-negative breast cancer (TNBC) lacks expressed protein targets, making therapy development challenging. Hydrogels offer a promising new route in this regard by improving the chemotherapeutic efficacy through increased solubility and sustained release. Moreover, subcutaneous hydrogel administration reduces patient burden by requiring less therapy and shorter treatment times. We recently established the design principles for the supramolecular assembly of single-domain coiled-coils into hydrogels. Using a modified computational design algorithm, we designed Q8, a hydrogel with rapid assembly for faster therapeutic hydrogel preparation. Q8 encapsulates and releases doxorubicin (Dox), enabling localized sustained release via subcutaneous injection. Remarkably, a single subcutaneous injection of Dox-laden Q8 (Q8•Dox) significantly suppresses tumors within just 1 week. This work showcases the bottom-up engineering of a fully protein-based drug delivery vehicle for improved TBNC treatment via noninvasive localized therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Advanced Biosensing Techniques and Applications · Cellular Mechanics and Interactions · Glycosylation and Glycoproteins Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States

Department of Microbiology, New York University Grossman School of Medicine, New York, New York 10016, United States

Center for Advanced Imaging Innovation and Research (CAI2R), New York University Grossman School of Medicine, New York, New York 10016, United States

Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York 10016, United States

Department of Radiation Oncology, New York University Grossman School of Medicine, New York, New York 10016, United States

Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn ,New York11201, United States

Department of Chemistry, New York University, New York, New York 10012, United States

Department of Biomaterials, New York University College of Dentistry, New York, New York 10010, United States

Funding

New York University · National Institutes of Health · National Science Foundation

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