DataVXACS Biomaterials Science & EngineeringPaper
journal article·2023-02-13Open access

High-Performance Implantable Sensors based on Anisotropic Magnetoresistive La0.67Sr0.33MnO3 for Biomedical Applications

Arturo Vera, Isidoro Martínez, Luiz Guilherme Enger, Bruno Guillet, Rubén Guerrero, José Manuel Diez, Olivier Rousseau, Marc Lam Chok Sing, Victor Pierron, Paolo Perna, Jaime J. Hernández, Isabel Rodríguez, Ivo Calaresu, Anja Meier, Carmen Huck, Ana Domínguez-Bajo, Ankor González-Mayorga, Elisa López-Dolado, María C. Serrano, Laura Ballerini, Lucas Pérez, Rodolfo Miranda, Stéphane Flament, María Teresa González, Laurence Méchin, Julio Camarero

ACS Biomaterials Science & Engineering· Volume 9· Issue 2
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Abstract

High Resolution Image Download MS PowerPoint Slide We present the design, fabrication, and characterization of an implantable neural interface based on anisotropic magnetoresistive (AMR) magnetic-field sensors that combine reduced size and high performance at body temperature. The sensors are based on La 0.67 Sr 0.33 MnO 3 (LSMO) as a ferromagnetic material, whose epitaxial growth has been suitably engineered to get uniaxial anisotropy and large AMR output together with low noise even at low frequencies. The performance of LSMO sensors of different film thickness and at different temperatures close to 37 °C has to be explored to find an optimum sensitivity of ∼400%/T (with typical detectivity values of 2 nT·Hz –1/2 at a frequency of 1 Hz and 0.3 nT·Hz –1/2 at 1 kHz), fitted for the detection of low magnetic signals coming from neural activity. Biocompatibility tests of devices consisting of submillimeter-size LSMO sensors coated by a thin poly(dimethyl siloxane) polymeric layer, both in vitro and in vivo, support their high suitability as implantable detectors of low-frequency biological magnetic signals emerging from heterogeneous electrically active tissues.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Atomic and Subatomic Physics Research · Magnetic and transport properties of perovskites and related materials · Advanced MRI Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fundación IMDEA Nanociencia, Calle Faraday 9, Madrid 28049, Spain

Faculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid 28223, Spain

Normandie University, UNICAEN, ENSICAEN, CNRS, GREYC, Caen 14000, France

Departamento Física de la Materia Condensada, Universidad Autónoma de Madrid, Madrid 28049, Spain

International School for Advanced Studies (SISSA/ISAS), Via Bonomea 265, Trieste 34136, Italy

mfd-Diagnostics GmbH, Mikroforum Ring 5, Wendelsheim 55234, Germany

Instituto de Ciencia de Materiales de Madrid (ICMM), CSIC, Calle Sor Juana Inés de la Cruz 3, Madrid 28049, Spain

Hospital Nacional de Parapléjicos, SESCAM, Finca La Peraleda s/n, Toledo 45071, Spain

Research Unit of “Design and Development of Biomaterials for Neural Regeneration”, Hospital Nacional de Parapléjicos, Joint Research Unit with CSIC, Toledo 45071, Spain

Dept. Física de Materiales, Universidad Complutense, Madrid 28040, Spain

Instituto “Nicolás Cabrera” and Condensed Matter Physics Center (IFIMAC), Universidad Autónoma de Madrid, Madrid 28049, Spain

Funding

Comunidad de Madrid · Ministerio de Ciencia e Innovaci?n · H2020 Future and Emerging Technologies

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