DataVXACS Biomaterials Science & EngineeringPaper
journal article·2023-01-09Open access

Synthesis and Characterization of a Biocompatible Nanoplatform Based on Silica-Embedded SPIONs Functionalized with Polydopamine

Miriam Romano, Manuel Antonio González Gómez, Pamela Santonicola, Noemi Aloi, Svenja Offer, Jana Pantzke, Samuele Raccosta, Valeria Longo, Alessandro Surpi, Silvia Alacqua, Giuseppina Zampi, Valentin Alek Dediu, Bernhard Michalke, Ralf Zimmerman, Mauro Manno, Yolanda Piñeiro, Paolo Colombo, Elia Di Schiavi, José Rivas, Paolo Bergese, Sebastiano Di Bucchianico

ACS Biomaterials Science & Engineering· Volume 9· Issue 1
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Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that have entered the clinical trials have been withdrawn due to toxicity concerns. Therefore, there is an urgent need to design low-risk and biocompatible SPION formulations. In this work, we present an original safe-by-design nanoplatform made of silica nanoparticles loaded with SPIONs and decorated with polydopamine (SPIONs@SiO2-PDA) and the study of its biocompatibility performance by an ad hoc thorough in vitro to in vivo nanotoxicological methodology. The results indicate that the SPIONs@SiO 2 -PDA have excellent colloidal stability in serum-supplemented culture media, even after long-term (24 h) exposure, showing no cytotoxic or genotoxic effects in vitro and ex vivo. Physiological responses, evaluated in vivo using Caenorhabditis elegans as the animal model, showed no impact on fertility and embryonic viability, induction of an oxidative stress response, and a mild impact on animal locomotion. These tests indicate that the synergistic combination of the silica matrix and PDA coating we developed effectively protects the SPIONs, providing enhanced colloidal stability and excellent biocompatibility.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoparticles: synthesis and applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Molecular and Translational Medicine, University of Brescia, Brescia25123, Italy

Center for Colloid and Surface Science (CSGI), Florence50019, Italy

Joint Mass Spectrometry Center (JMSC) at Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg85764, Germany

NANOMAG Laboratory, Applied Physics Department, iMATUS Materials Institute, Universidade de Santiago de Compostela, Santiago de Compostela15782, Spain

Institute of Biosciences and BioResources (IBBR), National Research Council of Italy (CNR), Naples80131, Italy

Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Palermo90146, Italy

Institute of Biophysics (IBF), National Research Council of Italy (CNR), Palermo90146, Italy

Institute of Nanostructured Materials (ISMN), National Research Council of Italy (CNR), Bologna40129, Italy

Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg85764, Germany

Funding

European Commission · National Research Council Italy

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