journal article·2023-03-13

Visible Light-Responsive Selenium Nanoparticles Combined with Sonodynamic Therapy to Promote Wound Healing

Wenjing Huang, Binbin Hu, Yalin Yuan, Huaqiang Fang, Junkai Jiang, Qun Li, Yi Zhuo, Xuetao Yang, Jinlu Wei, Xiaolei Wang

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Abstract

In this paper, we synthesized selenium nanoparticles (SeNPs) that could be effectively excited by pure yellow light (YL) source to enhance antibacterial ability. Meanwhile, YL could also play the role of anti-inflammatory and promote wound healing. In addition, in order to overcome the problem of low penetration depth of photodynamic therapy (PDT), SeNPs were encapsulated with polyethylenimine (PEI), then modified with the sound sensitive agent indocyanine green (ICG), realizing the combined photoacoustic therapy to promote the healing of wounds infected by drug-resistant bacteria. The antibacterial efficiency of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli ( E. coli ) reached more than 99% in in vitro and in vivo experiments within 10 min, which could safely and quickly kill drug-resistant bacteria to repair and heal wounds.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Medical and Biological Ozone Research · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi330088, P. R. China

School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi330088, P. R. China

Funding

Key Research and Development Program of Jiangxi Province · National Natural Science Foundation of China · Key Youth Project of Jiangxi Province

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