Multifunctional Hybrid Liposome as a Theranostic Platform for Magnetic Resonance Imaging Guided Photothermal Therapy

Chunyang Zhang; Dan Wu; Liejing Lu; Xiaohui Duan; Jie Liu; Xiaoyan Xie; Xintao Shuai; Jun Shen; Zhong Cao

doi:10.1021/acsbiomaterials.8b00176

journal article·2018-07-09

Multifunctional Hybrid Liposome as a Theranostic Platform for Magnetic Resonance Imaging Guided Photothermal Therapy

Chunyang Zhang, Dan Wu, Liejing Lu, Xiaohui Duan, Jie Liu, Xiaoyan Xie, Xintao Shuai, Jun Shen, Zhong Cao

ACS Biomaterials Science & Engineering· Volume 4· Issue 7

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Source abstract

Abstract

Photothermal therapy (PTT) is an emerging modality for cancer treatment owing to its localized treatment of tumors and easy combination with other therapeutic approaches. An imaging guided tumor ablation will facilitate the implementation of the treatment to boost efficiency. A type of multifunctional hybrid liposome is synthesized by loading indocyanine green (ICG) into a hybrid liposome based on a mixture of hybrid lipid and 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine–diethylene triamine pentacetate acid–gadopentetate dimeglumine (DMPE-DTPA-Gd). The hybrid liposome exhibited high structure stability and narrow size distribution in aqueous media. According to magnetic resonance imaging (MRI), hybrid liposome after tail vein injection accumulated effectively in subcutaneous CT-26 tumor of mice. Moreover, photothermal therapy is able to ablate tumor effectively under MR imaging guidance. Thus, the MRI visible PTT agent-loaded theranostic nanoplatform is promising for effective cancer treatment.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 West Yanjiang Road, Guangzhou 510120, China

Department of Medical Ultrasound, Institute of Diagnostic and Interventional Ultrasound, First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, China

PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, No. 135 West Xingang Road, Guangzhou 510275, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Guangzhou Municipality · Guangdong Province · Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme

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