journal article·2023-09-11

Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

Sagnik Nag, Bikramjit Bhattacharya, Swagata Dutta, Debashmita Mandal, Sayantanee Mukherjee, Krishnan Anand, Rajalakshmanan Eswaramoorthy, Nanasaheb Thorat, Saurabh Kumar Jha, Sukhamoy Gorai

Publisher page

Abstract

Glioblastoma (GBM) is an aggressive type of cancer that has led to the death of a large population. The traditional approach fails to develop a solution for GBM's suffering life. Extensive research into tumor microenvironments (TME) indicates that TME extracellular vesicles (EVs) play a vital role in cancer development and progression. EVs are classified into microvacuoles, apoptotic bodies, and exosomes. Exosomes are the most highlighted domains in cancer research. GBM cell-derived exosomes participate in multiple cancer progression events such as immune suppression, angiogenesis, premetastatic niche formation (PMN), ECM (extracellular matrix), EMT (epithelial-to-mesenchymal transition), metastasis, cancer stem cell development and therapeutic and drug resistance. GBM exosomes also carry the signature of a glioblastoma-related status. The exosome-based GBM examination is part of the new generation of liquid biopsy. It also solved early diagnostic limitations in GBM. Traditional therapeutic approaches do not cross the blood-brain barrier (BBB). Exosomes are a game changer in GBM treatment and it is emerging as a potential platform for effective, efficient, and specific therapeutic development. In this review, we have explored the exosome-GBM interlink, the clinical impact of exosomes on GBM biomarkers, the therapeutics signature of exosomes in GBM, exosome-based research challenges, and future directions in GBM. Therefore, the GBM-derived exosomes offer unique therapeutic opportunities, which are currently under preclinical and clinical testing.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Extracellular vesicles in disease · MicroRNA in disease regulation · Circular RNAs in diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biosciences, School of Biosciences & Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India

Department of Applied Microbiology, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India

Department of Agricultural and food Engineering, IIT Kharagpur, Kharagpur, West Bengal 721302, India

Department of Biotechnology, Maulana Abul Kalam Azad University of Technology (MAKAUT), Haringhata, Nadia, West Bengal 741249, India

Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India

Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa

Department of Biomaterials, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha institute of Medical and Technical sciences (SIMATS) Chennai 600077, India

Limerick Digital Cancer Research Centre and Department of Physics, Bernal Institute, University of Limerick, Castletroy, Co. Limerick, Limerick V94T9PX, Ireland

Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Knowledge Park-III, Institutional Area, Greater Noida 201310, India

Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India

Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India

Rush University Medical Center, 1620 W Harrison Street, Chicago, Illinois 60612, United States

References (100+)

Show source-provided references
1. 10.4161/epi.2544010.4161/epi.25440 ↗
2. 10.1007/s11060-017-2471-310.1007/s11060-017-2471-3 ↗
3. 10.1016/S0140-6736(18)30990-510.1016/S0140-6736(18)30990-5 ↗
4. 10.1007/s11060-017-2471-310.1007/s11060-017-2471-3 ↗
5. 10.1007/s11060-012-0958-510.1007/s11060-012-0958-5 ↗
6. 10.1038/s41416-019-0603-610.1038/s41416-019-0603-6 ↗
7. 10.1002/ctd2.21810.1002/ctd2.218 ↗
8. 10.1186/s12964-021-00760-910.1186/s12964-021-00760-9 ↗
9. 10.1016/j.isci.2020.10142010.1016/j.isci.2020.101420 ↗
10. 10.1016/j.ajps.2020.02.00410.1016/j.ajps.2020.02.004 ↗
11. 10.1016/j.bioactmat.2021.01.00910.1016/j.bioactmat.2021.01.009 ↗
12. 10.3390/cancers1317443510.3390/cancers13174435 ↗
13. 10.3389/fonc.2021.73352910.3389/fonc.2021.733529 ↗
14. 10.1007/s11060-021-03933-110.1007/s11060-021-03933-1 ↗
15. 10.1021/acsbiomaterials.1c0021710.1021/acsbiomaterials.1c00217 ↗
16. 10.3390/jcm902043610.3390/jcm9020436 ↗
17. 10.1038/s41596-019-0245-410.1038/s41596-019-0245-4 ↗
18. 10.1021/acsabm.3c0019910.1021/acsabm.3c00199 ↗
19. 10.1080/1354750X.2023.222953710.1080/1354750X.2023.2229537 ↗
20. 10.1016/j.devcel.2011.05.01510.1016/j.devcel.2011.05.015 ↗
21. 10.1080/1354750X.2022.206723310.1080/1354750X.2022.2067233 ↗
22. 10.1007/s13205-022-03217-z10.1007/s13205-022-03217-z ↗
23. 10.1038/nature0884910.1038/nature08849 ↗
24. 10.3389/fonc.2022.100744610.3389/fonc.2022.1007446 ↗
25. 10.1042/BST039055910.1042/BST0390559 ↗
26. 10.1016/j.devcel.2011.08.01910.1016/j.devcel.2011.08.019 ↗
27. 10.1016/j.ajps.2017.07.00810.1016/j.ajps.2017.07.008 ↗
28. 10.1208/s12248-016-0015-y10.1208/s12248-016-0015-y ↗
29. 10.1016/j.febslet.2015.04.03610.1016/j.febslet.2015.04.036 ↗
30. 10.2478/s11658-010-0023-310.2478/s11658-010-0023-3 ↗
31. 10.1261/rna.035352.11210.1261/rna.035352.112 ↗
32. 10.1016/j.celrep.2014.07.03510.1016/j.celrep.2014.07.035 ↗
33. 10.1186/1745-6150-8-1210.1186/1745-6150-8-12 ↗
34. 10.1038/ncomms398010.1038/ncomms3980 ↗
35. 10.1016/j.nbd.2012.06.00410.1016/j.nbd.2012.06.004 ↗
36. 10.1111/cas.1364210.1111/cas.13642 ↗
37. 10.1038/nm.398110.1038/nm.3981 ↗
38. 10.3892/ijo.2018.464410.3892/ijo.2018.4644 ↗
39. 10.3390/cells1114213010.3390/cells11142130 ↗
40. 10.1093/jnci/djx16610.1093/jnci/djx166 ↗
41. 10.1186/s12964-021-00809-910.1186/s12964-021-00809-9 ↗
42. 10.1038/nrg137910.1038/nrg1379 ↗
43. 10.18632/oncotarget.2803910.18632/oncotarget.28039 ↗
44. 10.1080/15384101.2021.193035710.1080/15384101.2021.1930357 ↗
45. 10.1007/s13402-017-0355-310.1007/s13402-017-0355-3 ↗
46. 10.1158/1078-0432.CCR-12-096210.1158/1078-0432.CCR-12-0962 ↗
47. 10.1126/sciimmunol.aah550910.1126/sciimmunol.aah5509 ↗
48. 10.1093/neuonc/nov24410.1093/neuonc/nov244 ↗
49. 10.1038/s41388-019-0996-y10.1038/s41388-019-0996-y ↗
50. 10.3390/ijms2111399010.3390/ijms21113990 ↗
51. 10.1080/2162402X.2017.141290910.1080/2162402X.2017.1412909 ↗
52. 10.1007/s12264-020-00626-z10.1007/s12264-020-00626-z ↗
53. 10.3390/ijms1902043610.3390/ijms19020436 ↗
54. 10.1093/neuonc/nov24410.1093/neuonc/nov244 ↗
55. 10.1093/noajnl/vdaa05610.1093/noajnl/vdaa056 ↗
56. 10.2217/epi-2019-019310.2217/epi-2019-0193 ↗
57. 10.1038/nri.2016.11610.1038/nri.2016.116 ↗
58. 10.1016/j.imlet.2018.05.00210.1016/j.imlet.2018.05.002 ↗
59. 10.1038/s41419-020-03042-310.1038/s41419-020-03042-3 ↗
60. 10.1186/s12943-020-01189-310.1186/s12943-020-01189-3 ↗
61. 10.1158/2326-6066.CIR-19-024010.1158/2326-6066.CIR-19-0240 ↗
62. 10.1016/j.biocel.2014.10.00510.1016/j.biocel.2014.10.005 ↗
63. 10.1126/sciadv.aar276610.1126/sciadv.aar2766 ↗
64. 10.1002/ijc.3205210.1002/ijc.32052 ↗
65. 10.1038/s41388-018-0261-910.1038/s41388-018-0261-9 ↗
66. 10.1186/s13578-019-0282-210.1186/s13578-019-0282-2 ↗
67. 10.3390/ijms2014346110.3390/ijms20143461 ↗
68. 10.3390/ijms2024610910.3390/ijms20246109 ↗
69. 10.3389/fbioe.2019.0034110.3389/fbioe.2019.00341 ↗
70. 10.1038/s41467-020-18794-x10.1038/s41467-020-18794-x ↗
71. 10.3389/fphar.2020.57906810.3389/fphar.2020.579068 ↗
72. 10.1016/j.omtm.2021.05.01610.1016/j.omtm.2021.05.016 ↗
73. 10.3389/fphys.2018.0065110.3389/fphys.2018.00651 ↗
74. 10.3892/ol.2017.556710.3892/ol.2017.5567 ↗
75. 10.1371/journal.pone.017223410.1371/journal.pone.0172234 ↗
76. 10.1002/em.2198810.1002/em.21988 ↗
77. 10.1098/rstb.2016.047710.1098/rstb.2016.0477 ↗
78. 10.1177/0271678X1665555110.1177/0271678X16655551 ↗
79. 10.1016/j.cellsig.2011.10.00810.1016/j.cellsig.2011.10.008 ↗
80. 10.2147/CMAR.S23342310.2147/CMAR.S233423 ↗
81. 10.1038/s42003-019-0560-x10.1038/s42003-019-0560-x ↗
82. 10.3389/fimmu.2015.0020110.3389/fimmu.2015.00201 ↗
83. 10.1158/1541-7786.MCR-13-062910.1158/1541-7786.MCR-13-0629 ↗
84. 10.18632/oncotarget.1363810.18632/oncotarget.13638 ↗
85. 10.1002/jcp.3086710.1002/jcp.30867 ↗
86. 10.1111/jcmm.1775510.1111/jcmm.17755 ↗
87. 10.1186/s12943-019-0995-110.1186/s12943-019-0995-1 ↗
88. 10.1016/j.yexcr.2017.08.03210.1016/j.yexcr.2017.08.032 ↗
89. 10.1080/20013078.2017.135947910.1080/20013078.2017.1359479 ↗
90. 10.1016/j.semcancer.2019.09.00410.1016/j.semcancer.2019.09.004 ↗
91. 10.3389/fonc.2019.0137010.3389/fonc.2019.01370 ↗
92. 10.1186/s12951-020-00722-210.1186/s12951-020-00722-2 ↗
93. 10.1016/j.biopha.2022.11265710.1016/j.biopha.2022.112657 ↗
94. 10.1016/j.devcel.2019.04.01110.1016/j.devcel.2019.04.011 ↗
95. 10.3390/ijms2004084010.3390/ijms20040840 ↗
96. 10.1016/j.bulcan.2018.05.00310.1016/j.bulcan.2018.05.003 ↗
97. 10.18632/oncotarget.1694910.18632/oncotarget.16949 ↗
98. 10.2147/IJN.S27179510.2147/IJN.S271795 ↗
99. 10.1002/iub.238310.1002/iub.2383 ↗
100. 10.3389/fonc.2019.0117610.3389/fonc.2019.01176 ↗