DataVXACS Biomaterials Science & EngineeringPaper
journal article·2022-04-11

Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy

Qin Liu, Ping Song, Weiwei Zhang, Zhenyu Wang, Kai Yang, Jianquan Luo, Longbao Zhu, Lin Gui, Yugui Tao, Fei Ge

ACS Biomaterials Science & Engineering· Volume 8· Issue 4
Publisher page
Source abstract

Abstract

The combination of multiple treatments has recently been investigated for tumor treatment. In this study, molybdenum disulfide (MoS2) with excellent photothermal conversion performance was used as the core, and manganese dioxide (MnO2), which responds to the tumor microenvironment, was loaded on its surface by liquid deposition to form a mesoporous core–shell structure. Then, the chemotherapeutic drug Adriamycin (DOX) was loaded into the hole. To further enhance its water solubility and stability, the surface of MnO2 was modified with mPEG-NH2 to prepare the combined antitumor nanocomposite MoS2@DOX/MnO2-PEG (MDMP). The results showed that MDMP had a diameter of about 236 nm, its photothermal conversion efficiency was 33.7%, and the loading and release rates of DOX were 13 and 65%, respectively. During in vivo and in vitro studies, MDMP showed excellent antitumor activity. Under the combined treatment, the tumor cell viability rate was only 11.8%. This nanocomposite exhibits considerable potential for chemo-photothermal combined antitumor therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsMaterials processing

OpenAlex topics: Nanoplatforms for cancer theranostics · MXene and MAX Phase Materials · Advanced Photocatalysis Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, People’s Republic of China

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, China

Institute of Process Engineering, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

Department of Microbiology and Immunology, Wannan Medical College, Wuhu, Anhui 241002, Peoples Republic of China

Funding

Anhui Polytechnic University · Wannan Medical College · Anhui University · National Natural Science Foundation of China · Natural Science Foundation of Anhui Province · Anhui Provincial Higher Education Institutes

References (44)

Show source-provided references
1. 10.1016/j.carbpol.2021.11836610.1016/j.carbpol.2021.118366 ↗
2. 10.1002/adma.20170683110.1002/adma.201706831 ↗
3. 10.7150/thno.4071510.7150/thno.40715 ↗
4. 10.1016/j.biomaterials.2020.12010610.1016/j.biomaterials.2020.120106 ↗
5. 10.1158/1078-0432.CCR-16-087010.1158/1078-0432.CCR-16-0870 ↗
6. 10.2174/187152062066620080410371410.2174/1871520620666200804103714 ↗
7. 10.1080/1061186X.2021.189212110.1080/1061186X.2021.1892121 ↗
8. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗
9. 10.1016/j.carbpol.2019.03.08510.1016/j.carbpol.2019.03.085 ↗
10. 10.34133/2020/942645310.34133/2020/9426453 ↗
11. 10.1021/acsami.9b0703710.1021/acsami.9b07037 ↗
12. 10.1016/j.colsurfa.2016.11.06210.1016/j.colsurfa.2016.11.062 ↗
13. 10.1016/j.biomaterials.2021.12092610.1016/j.biomaterials.2021.120926 ↗
14. 10.1002/anie.20120922910.1002/anie.201209229 ↗
15. 10.1021/acsami.9b1696210.1021/acsami.9b16962 ↗
16. 10.1016/j.colsurfb.2018.11.03010.1016/j.colsurfb.2018.11.030 ↗
17. 10.1002/smll.20190487010.1002/smll.201904870 ↗
18. 10.1039/c6nr00150e10.1039/c6nr00150e ↗
19. 10.1002/advs.20160054010.1002/advs.201600540 ↗
20. 10.1039/c6tb03352k10.1039/c6tb03352k ↗
21. 10.1016/j.jcis.2019.02.01110.1016/j.jcis.2019.02.011 ↗
22. 10.1021/ac501201410.1021/ac5012014 ↗
23. 10.1016/j.microc.2020.10515410.1016/j.microc.2020.105154 ↗
24. 10.1021/acsami.8b1892410.1021/acsami.8b18924 ↗
25. 10.1039/d1fo00032b10.1039/d1fo00032b ↗
26. 10.1007/s10895-020-02661-510.1007/s10895-020-02661-5 ↗
27. 10.3390/cancers1316394810.3390/cancers13163948 ↗
28. 10.7150/thno.5570810.7150/thno.55708 ↗
29. 10.1002/adma.20180593610.1002/adma.201805936 ↗
30. 10.1002/adma.20200448110.1002/adma.202004481 ↗
31. 10.1016/j.biomaterials.2017.11.01510.1016/j.biomaterials.2017.11.015 ↗
32. 10.1016/j.cej.2019.12207910.1016/j.cej.2019.122079 ↗
33. 10.1021/acs.bioconjchem.0c0020910.1021/acs.bioconjchem.0c00209 ↗
34. 10.1002/advs.20190334110.1002/advs.201903341 ↗
35. 10.1021/acsbiomaterials.0c0050710.1021/acsbiomaterials.0c00507 ↗
36. 10.1016/j.aca.2020.09.01010.1016/j.aca.2020.09.010 ↗
37. 10.1002/smll.20200058910.1002/smll.202000589 ↗
38. 10.1038/s41467-017-01050-010.1038/s41467-017-01050-0 ↗
39. 10.1016/j.cjche.2019.12.01310.1016/j.cjche.2019.12.013 ↗
40. 10.1039/d0tb01373k10.1039/d0tb01373k ↗
41. 10.1016/j.colsurfb.2019.11058510.1016/j.colsurfb.2019.110585 ↗
42. 10.1021/ja201269b10.1021/ja201269b ↗
43. 10.1039/c7nr08747k10.1039/c7nr08747k ↗
44. 10.1007/s10856-008-3577-010.1007/s10856-008-3577-0 ↗