Human Induced Pluripotent Stem Cell Derived Neural Stem Cell Survival and Neural Differentiation on Polyethylene Glycol Dimethacrylate Hydrogels Containing a Continuous Concentration Gradient of N-Cadherin Derived Peptide His-Ala-Val-Asp-Ile
Source abstract
Abstract
Although preclinical models of spinal cord injury have shown that matrix inclusion in stem cell therapy leads to greater neurological improvements than that including cells alone, there has been insufficient matrix optimization for human cells. N -Cadherin influences the development and maintenance of neural tissue, but the effects of N -cadherin derived peptide His-Ala-Val-Asp-Ile (HAVDI) on the survival, neurite extension, and expression of neural differentiation markers in human induced pluripotent stem cell derived neural stems (hNSC) have not been widely examined. Using polyethylene glycol hydrogels containing a continuous gradient of HAVDI, this study identifies concentration dependent effects on hNSC survival and neural differentiation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · Pluripotent Stem Cells Research · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Vivian L. Smith Department of Neurosurgery and Center for Stem Cells and Regenerative Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston, 1825 Pressler, Houston, Texas 77030, United States
Department of Nanomedicine and Biomedical Engineering, McGovern Medical School at the University of Texas Health Science Center at Houston, 1825 Pressler, Houston, Texas 77030, United States
Funding
Memorial Hermann Foundation · Mission Connect, a TIRR program · Vivian L. Smith Department of Neurosurgery
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